Single lung transplantation for lymphangioleiomyomatosis: a single-center experience in Japan

Single lung transplantation for lymphangioleiomyomatosis: a single-center experience in Japan Purpose Lung transplantation is accepted as an effective modality for patients with end-stage pulmonary lymphangioleio- myomatosis (LAM). Generally, bilateral lung transplantation is preferred to single lung transplantation (SLT) for LAM because of native lung-related complications, such as pneumothorax and chylothorax. It remains controversial whether SLT is a suitable surgical option for LAM. The objective of this study was to evaluate the morbidity, mortality and outcome after SLT for LAM in a lung transplant center in Japan. Methods We reviewed the records of 29 patients who underwent SLT for LAM in our hospital between March, 2000 and November, 2017. The data collected included the pre-transplant demographics of recipients, surgical characteristics, com- plications, morbidity, mortality and survival after SLT for LAM. Results The most common complication after SLT for LAM was contralateral pneumothorax (n = 7; 24.1%). Six of these recipients were treated successfully with chest-tube placement and none required surgery for the pneumothorax. The second- most common complication was chylous pleural effusion (n = 6; 20.7%) and these recipients were all successfully treated by pleurodesis. The 5-year survival rate after SLT for LAM was 79.5%. Conclusion LAM-related complications after SLT for this disease can be managed. SLT is a treatment http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Surgery Today Springer Journals

Single lung transplantation for lymphangioleiomyomatosis: a single-center experience in Japan

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Nature Singapore Pte Ltd.
Subject
Medicine & Public Health; Surgery; Surgical Oncology
ISSN
0941-1291
eISSN
1436-2813
D.O.I.
10.1007/s00595-018-1678-z
Publisher site
See Article on Publisher Site

Abstract

Purpose Lung transplantation is accepted as an effective modality for patients with end-stage pulmonary lymphangioleio- myomatosis (LAM). Generally, bilateral lung transplantation is preferred to single lung transplantation (SLT) for LAM because of native lung-related complications, such as pneumothorax and chylothorax. It remains controversial whether SLT is a suitable surgical option for LAM. The objective of this study was to evaluate the morbidity, mortality and outcome after SLT for LAM in a lung transplant center in Japan. Methods We reviewed the records of 29 patients who underwent SLT for LAM in our hospital between March, 2000 and November, 2017. The data collected included the pre-transplant demographics of recipients, surgical characteristics, com- plications, morbidity, mortality and survival after SLT for LAM. Results The most common complication after SLT for LAM was contralateral pneumothorax (n = 7; 24.1%). Six of these recipients were treated successfully with chest-tube placement and none required surgery for the pneumothorax. The second- most common complication was chylous pleural effusion (n = 6; 20.7%) and these recipients were all successfully treated by pleurodesis. The 5-year survival rate after SLT for LAM was 79.5%. Conclusion LAM-related complications after SLT for this disease can be managed. SLT is a treatment

Journal

Surgery TodaySpringer Journals

Published: May 28, 2018

References

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