Single electron localisation on the cystine/cysteine couple: sulphur or carbon?

Single electron localisation on the cystine/cysteine couple: sulphur or carbon? Protein sulphur functions can host a single electron on sulphur atoms in redox processes linking thiols to disulphides. However, experimental results have shown that the single electron can also reside on carbon atoms leading to protein damage. We have investigated this possibility on cystine for two initial conformations. The other site of electron fixation is always the carbonyl function. When there is no carbonyl, the electron remains on the sulphur atoms. In a model of the active site of thioredoxin (cystine, the carboxylic group of aspartic acid 30 and a water molecule), only the carbonyl group of the cystine is reactive. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Research on Chemical Intermediates Springer Journals

Single electron localisation on the cystine/cysteine couple: sulphur or carbon?

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Publisher
Springer Netherlands
Copyright
Copyright © 2009 by Springer Science+Business Media BV
Subject
Chemistry; Inorganic Chemistry ; Physical Chemistry ; Catalysis
ISSN
0922-6168
eISSN
1568-5675
D.O.I.
10.1007/s11164-009-0041-9
Publisher site
See Article on Publisher Site

Abstract

Protein sulphur functions can host a single electron on sulphur atoms in redox processes linking thiols to disulphides. However, experimental results have shown that the single electron can also reside on carbon atoms leading to protein damage. We have investigated this possibility on cystine for two initial conformations. The other site of electron fixation is always the carbonyl function. When there is no carbonyl, the electron remains on the sulphur atoms. In a model of the active site of thioredoxin (cystine, the carboxylic group of aspartic acid 30 and a water molecule), only the carbonyl group of the cystine is reactive.

Journal

Research on Chemical IntermediatesSpringer Journals

Published: Jun 23, 2009

References

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