Single-dose botulinum toxin type a compared with repeated-dose for treatment of trigeminal neuralgia: a pilot study

Single-dose botulinum toxin type a compared with repeated-dose for treatment of trigeminal... Background: Several RCT studies including ours, seem to prove the role of Botulinum toxin type A (BTX-A) in the treatment of trigeminal neuralgia (TN), but no standardized dosing regimen has been established. In our study, we compare two different methods of administration: single-dose or repeated-dose strategy which was most frequently applied over the years in our centre. Methods: An open-label trail was conducted. One hundred patients with classic TN symptoms were recruited, and randomly and equally apportioned to single- or repeated-dose group. Patients in the single-dose group received a local BTX-A injection of 70 to 100 U. The repeated-dose group received an initial BTX-A injection of 50 to 70 U and then another of equal volume 2 weeks later. All patients were followed for 6 months. Results: In the single- and repeated-dose groups, 44 and 37, respectively, completed the entire study. The groups were statistically similar in TN frequency, time between treatment and effect, time to peak effect, VAS scores, and rates of adverse reactions (latency and duration). However, the single-dose group experienced significantly longer duration of effect (P = 0.032). Conclusions: The single- and repeated-dosing BTX-A regimens were largely comparable in efficacy and safety. This study suggests that http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Headache and Pain Springer Journals

Single-dose botulinum toxin type a compared with repeated-dose for treatment of trigeminal neuralgia: a pilot study

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Publisher
Springer Milan
Copyright
Copyright © 2017 by The Author(s).
Subject
Medicine & Public Health; Pain Medicine; Internal Medicine; Neurology
ISSN
1129-2369
eISSN
1129-2377
D.O.I.
10.1186/s10194-017-0793-3
Publisher site
See Article on Publisher Site

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