Single and chronic l-serine treatments exert antidepressant-like effects in rats possibly by different means

Single and chronic l-serine treatments exert antidepressant-like effects in rats possibly by... In the present study, the effects of both single (6 mmol l-serine/10 ml/kg orally administrated) and chronic (2% l-serine solution freely given for 28 days) treatments on depression-like behavior were evaluated in Wistar rats, representing the control, and Wistar Kyoto rats, representing an animal model of depression. Both single and chronic l-serine treatments decreased the duration of immobility, which is an index of a depressive-like state, in the forced swimming test in both strains. However, the decreases in the duration of immobility appear to be regulated differently by the different mechanisms involved in single and chronic l-serine treatments. In the prefrontal cortex and hippocampus, single l-serine treatment increased the concentrations of l-serine, but not d-serine, while chronic l-serine treatment increased those of d-serine, but not l-serine. These data suggest that the antidepressant-like effects of single and chronic l-serine treatments may have been induced by the increased l-serine and d-serine concentrations, respectively, in the brain. In addition, chronic l-serine treatment increased cystathionine concentrations in the hippocampus and prefrontal cortex in Wistar rats, but not in Wistar Kyoto rats, suggesting that Wistar Kyoto rats have an abnormality in the serine–cystathionine metabolic pathway. In conclusion, single and chronic l-serine treatments may induce antidepressant-like effects via the different mechanisms related to serine metabolism in the brain. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Amino Acids Springer Journals

Single and chronic l-serine treatments exert antidepressant-like effects in rats possibly by different means

Loading next page...
 
/lp/springer_journal/single-and-chronic-l-serine-treatments-exert-antidepressant-like-whCH6ev4XU
Publisher
Springer Vienna
Copyright
Copyright © 2017 by Springer-Verlag GmbH Austria
Subject
Life Sciences; Biochemistry, general; Analytical Chemistry; Biochemical Engineering; Life Sciences, general; Proteomics; Neurobiology
ISSN
0939-4451
eISSN
1438-2199
D.O.I.
10.1007/s00726-017-2448-8
Publisher site
See Article on Publisher Site

Abstract

In the present study, the effects of both single (6 mmol l-serine/10 ml/kg orally administrated) and chronic (2% l-serine solution freely given for 28 days) treatments on depression-like behavior were evaluated in Wistar rats, representing the control, and Wistar Kyoto rats, representing an animal model of depression. Both single and chronic l-serine treatments decreased the duration of immobility, which is an index of a depressive-like state, in the forced swimming test in both strains. However, the decreases in the duration of immobility appear to be regulated differently by the different mechanisms involved in single and chronic l-serine treatments. In the prefrontal cortex and hippocampus, single l-serine treatment increased the concentrations of l-serine, but not d-serine, while chronic l-serine treatment increased those of d-serine, but not l-serine. These data suggest that the antidepressant-like effects of single and chronic l-serine treatments may have been induced by the increased l-serine and d-serine concentrations, respectively, in the brain. In addition, chronic l-serine treatment increased cystathionine concentrations in the hippocampus and prefrontal cortex in Wistar rats, but not in Wistar Kyoto rats, suggesting that Wistar Kyoto rats have an abnormality in the serine–cystathionine metabolic pathway. In conclusion, single and chronic l-serine treatments may induce antidepressant-like effects via the different mechanisms related to serine metabolism in the brain.

Journal

Amino AcidsSpringer Journals

Published: Jun 6, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off