Cardiovasc Intervent Radiol (2018) 41:1089–1094 https://doi.org/10.1007/s00270-018-1950-z LABORATORY INVESTIGATION Single 15-Min Protocol Yields the Same Cryoablation Size and Margin as the Conventional 10–8–10-Min Protocol: Results of Kidney and Liver Swine Experiment 1 2 3 4 • • • • John D. Werner Aline C. Tregnago George J. Netto Constantine Frangakis Christos S. Georgiades Received: 18 January 2018 / Accepted: 28 March 2018 / Published online: 12 April 2018 Springer Science+Business Media, LLC, part of Springer Nature and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2018 Abstract infused via an angiographic catheter in hepatic or renal Introduction The objective was to determine the ablation artery to stain the non-frozen tissue. Animals were eutha- size of a single 15-min freeze and compare it with the nized and organs examined macro- and microscopically. conventional 10-min freeze–8-min thaw–10-min freeze Results Three histological regions were observed: (A) a protocol. Secondary objectives were to determine the viable/stained region representing the tissue outside the ablation margin and to ascertain whether islands of viable ice-ball, (B) a central necrotic area representing the ablated tissue remain within the ablation zone. region within the ice-ball and (C) an unstained but viable Materials and Methods Five adult swine under
CardioVascular and Interventional Radiology – Springer Journals
Published: Apr 12, 2018
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