Chromatographia (2017) 80:1361–1369 DOI 10.1007/s10337-017-3365-4 ORIGINAL Simultaneous Determination of Seven Components in Human Plasma by LC–ESI–MS/MS After Oral Administration of Danqi Tablets with Application to a Pharmacokinetic Study 1 1 Jiawei Shen · Xiuqin Cao Received: 24 April 2017 / Revised: 14 July 2017 / Accepted: 18 July 2017 / Published online: 31 July 2017 © Springer-Verlag GmbH Germany 2017 Abstract A rapid and sensitive LC/MS/MS method has of Danqi tablets, which, in turn, aid in explaining the mech- been developed and validated for simultaneous determina- anism of its effectiveness and toxicity. tion of GRg1, GRb1, NGR1, tanshinone IIA, salvianolic acid B, dihydrotanshinone I, and danshensu in human Keywords LC/MS/MS · Danqi tablets · plasma after oral administration. The plasma samples were Pharmacokinetics · Human pretreated by protein precipitation with acetone–acetoni- trile–HCl (20:75:5, v/v/v). Separations were performed on a ACQUITY UPLC HSST3 column (50 mm × 2.1 mm, Introduction i.d., 1.8 μm) with gradient elution using 0.1% formic acid in water and 0.1% formic acid in a mixture of methanol/ Herbal medicines (HMs) have been an essential of the −1 acetonitrile (v:v; 1:1), at a flow rate of 0.3 mL min . The health care system in Asian countries and have been widely method was linear over the tested concentration ranges used
Chromatographia – Springer Journals
Published: Jul 31, 2017
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