World J Urol (2017) 35:1247–1254 DOI 10.1007/s00345-016-1993-1 ORIGINAL ARTICLE Simulated physiological stretch increases expression of extracellular matrix proteins in human bladder smooth muscle cells via integrin α4/αv‑FAK‑ERK1/2 signaling pathway 1 1 1 1 1 1 Shulian Chen · Chuandu Peng · Xin Wei · Deyi Luo · Yifei Lin · Tongxin Yang · 1 1 1 1 Xi Jin · Lina Gong · Hong Li · Kunjie Wang Received: 23 July 2016 / Accepted: 16 December 2016 / Published online: 24 December 2016 © Springer-Verlag Berlin Heidelberg 2016 Abstract under the simulated physiological stretch of 10 and 15%. Objectives To investigate the effect of simulated physi- Integrin α4 and αv, FAK, ERK1/2 were activated by 10% ological stretch on the expression of extracellular matrix simulated physiological stretch compared with the static (ECM) proteins and the role of integrin α4/αv, focal adhe- condition. Pretreatment of ERK1/2 inhibitor, FAK inhibi- sion kinase (FAK), extracellular regulated protein kinases tor, integrin α4 siRNA, or integrin αv siRNA reduced the 1/2 (ERK1/2) in the stretch-induced ECM protein expres- stretch-induced expression of ECM proteins. And FAK sion of human bladder smooth muscle cells (HBSMCs). inhibitor decreased the stretch-induced ERK1/2 activity Methods HBSMCs were seeded onto
World Journal of Urology – Springer Journals
Published: Dec 24, 2016
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