Besides the list of six characteristics of the so called “Human Adjuvant Disease” (HAD) described by Miyoshi in 1964 (13) a major obstacle to the general recognition of HAD has been the varying definitions of the disorder (1). In the original and most complete paper on the clinical findings of connective tissue disease after injection of foreign substances, published by Kumagai (11) in 1984, 18 patients were reported on and a review of 28 additional cases from the Japanese literature was presented. The patients were classified into 2 major groups: group I consisted of 24 patients with definite connective tissue disease and group II consisted of 22 patients with HAD with some symptoms, signs and laboratory findings suggestive but not diagnostic of any specific connective tissue disease. The patient described in this paper had clinical features comparable to a similar case described by Sergott (20) in 1986. The diagnosis was silicone mastitis and a possibly human adjuvant disease.
European Journal of Plastic Surgery – Springer Journals
Published: Feb 1, 1998
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