Silica nanosphere–graphene oxide (SiO2–GO) hybrid catalyzed facile synthesis of functionalized quinoxaline derivatives

Silica nanosphere–graphene oxide (SiO2–GO) hybrid catalyzed facile synthesis of... Electronic supplementary material The online version of this article (doi:10.1007/s11164-016-2667-8) contains supplementary material, which is available to authorized users. & Murlidhar S. Shingare Bhaskar R. Sathe Department of Chemistry, Dr. Babasaheb Ambedkar Marathwada University, Aurangabad 431004, India 123 830 P. V. Shitre et al. Keywords SiO nanospheres  Graphene oxide (GO)  SiO –GO nanohybrid 2 2 Functionalized quinoxaline  Cyclocondensation reaction Introduction Heterocyclic compounds have attracted considerable attention because of their ample biological activities and other pharmaceutical contributions. Interestingly, a variety of six-membered heterocycles with two nitrogen-containing heteroatoms have received meticulous attention recently. Likewise, quinoxaline derivatives have acquired tremendous scope due to their tunable and varied biological and pharmaceutical applications, especially for anti-bacterial [1], anti-cancer [2], anti- viral [3], anti-HIV [4], and kinase inhibition [5]. Moreover, they are also active ingredients of several anti-tumor agents such as chloroquinoxaline sulfonamide (CQS), NCGS5879-01 [6], and XK469 that are known to be effective by targeting different pathways leading to cancer. Furthermore, varenicline is used for treating nicotine addiction, and brimonidine is used for treating glaucoma [7, 8]. Apart from its medicinal significance, this scaffold finds wider technical applications in dye industries [9], efficient electron luminescent materials [10], organic semiconductors Research on Chemical Intermediates Springer Journals

Silica nanosphere–graphene oxide (SiO2–GO) hybrid catalyzed facile synthesis of functionalized quinoxaline derivatives

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Springer Netherlands
Copyright © 2016 by Springer Science+Business Media Dordrecht
Chemistry; Catalysis; Physical Chemistry; Inorganic Chemistry
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