Sildenafil

Sildenafil Reactions 1704, p341 - 2 Jun 2018 Melanoma: 2 case reports In a case report, a 46-year-old man and an 48-year-old man were described, who developed melanoma following treatment with sildenafil [Viagra; doses, routes, indications, durations of treatments to reactions onsets and outcomes not stated]. Case 1: A 46-year-old man developed a > 5mm lesion on his upper back. Biopsy revealed a superficial spreading melanoma showing four mitoses per square mm of tumour. The tumour was in close association with significantly dilated thin-walled blood vessels. Another dilated vessel was massively involved by tumour. The lesion was positive for immunostains Melan A (Mart 1), HMB45 and Ki67. He reported weekly use of sildenafil for seven years. Case 2: A 48-year-old man developed a 7.5 mm lesion on his lower back. Biopsy showed superficial spreading melanoma six mitoses per square mm of tumour. The tumour was adjacent to a massively dilated thin-walled blood vessel and another dilated vein heavily involved by tumour. The lesion was moderately positive for immunostains Melan A (Mart 1), HMB45 and Ki67. He reported use of sildenafil weekly or twice weekly for two years. Author comment: "We report a close association between markedly dilated vessels and melanoma on histopathology in two patients with long-standing use of sildenafil, providing evidence to support this association and provide a potential structural/physiological correlation." Lambert WC, et al. How sildenafil (Viagra) may cause melanoma: a histopathologic study providing a potential physiological/etiopathological mechanism. Journal of the European Academy of Dermatology and Venereology 32: e202-e204, No. 5, May 2018. Available from: URL: http://doi.org/10.1111/ jdv.14723 - USA 803323571 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Sildenafil

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Publisher
Springer International Publishing
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-018-46984-y
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p341 - 2 Jun 2018 Melanoma: 2 case reports In a case report, a 46-year-old man and an 48-year-old man were described, who developed melanoma following treatment with sildenafil [Viagra; doses, routes, indications, durations of treatments to reactions onsets and outcomes not stated]. Case 1: A 46-year-old man developed a > 5mm lesion on his upper back. Biopsy revealed a superficial spreading melanoma showing four mitoses per square mm of tumour. The tumour was in close association with significantly dilated thin-walled blood vessels. Another dilated vessel was massively involved by tumour. The lesion was positive for immunostains Melan A (Mart 1), HMB45 and Ki67. He reported weekly use of sildenafil for seven years. Case 2: A 48-year-old man developed a 7.5 mm lesion on his lower back. Biopsy showed superficial spreading melanoma six mitoses per square mm of tumour. The tumour was adjacent to a massively dilated thin-walled blood vessel and another dilated vein heavily involved by tumour. The lesion was moderately positive for immunostains Melan A (Mart 1), HMB45 and Ki67. He reported use of sildenafil weekly or twice weekly for two years. Author comment: "We report a close association between markedly dilated vessels and melanoma on histopathology in two patients with long-standing use of sildenafil, providing evidence to support this association and provide a potential structural/physiological correlation." Lambert WC, et al. How sildenafil (Viagra) may cause melanoma: a histopathologic study providing a potential physiological/etiopathological mechanism. Journal of the European Academy of Dermatology and Venereology 32: e202-e204, No. 5, May 2018. Available from: URL: http://doi.org/10.1111/ jdv.14723 - USA 803323571 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704

Journal

Reactions WeeklySpringer Journals

Published: Jun 2, 2018

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