Pathology & Oncology Research https://doi.org/10.1007/s12253-018-0437-1 LETTER TO THE EDITOR Significant Family History of Breast Cancer may Further Increase Risk of Pre-malignant and Malignant Lesions in Specimens from Breast Reduction Surgery Kadri Altundag Received: 1 January 2018 /Accepted: 30 May 2018 Arányi Lajos Foundation 2018 Dear Editor, breast cancer . Therefore, significant family history of I wish to congratulate Usón Junior and colleagues for their breast cancer may further increase risk of pre-malignant and article  in which they reviewed all pathology reports of 783 malignant lesions in specimens from breast reduction surgery. patients undergoing breast reduction surgery. Exclusion criteria were a personal history of breast cancer, unclear reason for mastectomy and incomplete data on the pathology report. The incidence of pre-malignant and malignant lesions in spec- References imens from breast reduction surgery is around 5% These al- terations were more likely to be found when 4 or more paraffin 1. Usón Junior PLS, Callegaro Filho D, Bugano DDG, Geyer FC, de Nigro Corpa MV, Gonçalves PDS, Simon SD, Kaliks RA (2018) blocks were sampled and when patients were older than Incidental Findings in Reduction Mammoplasty Specimens in 40 years-old. However, family history of breast cancer was Patients with No Prior History of Breast Cancer. An Analysis of not added to exclusion criteria. Metcalfe et al. found that 783 Specimens. Pathol Oncol Res 24(1):95–99 women with a significant family history of breast cancer (ie, 2. Metcalfe KA, Finch A, Poll A, Horsman D, Kim-Sing C, Scott J, Royer R, Sun P, Narod SA (2009) Breast cancer risks in women with two or more breast cancers under the age of 50 years, or three a family history of breast or ovarian cancer who have tested negative or more breast cancers at any age), but who test negative for for a BRCA1 or BRCA2 mutation. Br J Cancer 100(2):421–425 BRCA mutations have approximately a four-fold risk of * Kadri Altundag firstname.lastname@example.org MKA Breast Cancer Clinic, Tepe Prime, Cankaya, 06800 Ankara, Turkey
Pathology & Oncology Research – Springer Journals
Published: Jun 3, 2018
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