Significance of MNK1 in prognostic prediction and chemotherapy development of epithelial ovarian cancer

Significance of MNK1 in prognostic prediction and chemotherapy development of epithelial ovarian... Clin Transl Oncol (2017) 19:1107–1116 DOI 10.1007/s12094-017-1646-x RESEARCH AR TIC L E Significance of MNK1 in prognostic prediction and chemotherapy development of epithelial ovarian cancer 1 2 3 4 5 6 • • • • • S. Hou P. Du P. Wang C. Wang P. Liu H. Liu Received: 21 October 2016 / Accepted: 13 March 2017 / Published online: 22 March 2017 Federacio ´ n de Sociedades Espan ˜ olas de Oncologı ´a (FESEO) 2017 Abstract Methods Immunohistochemical (IHC) staining was used to Background Ovarian cancer is the most lethal gynecologic explore the expression pattern of mitogen-activated protein malignancy worldwide with surgery as the only curative kinase (MAPK)-interacting kinase 1 (MNK1) in tumor treatment. Long-term overall survival (OS) of ovarian tissues from 138 epithelial ovarian cancer (EOC) patients. cancer is far from satisfactory, even though significant Clinicopathological data were subjected to Kaplan–Meier improvement has been made in post-operative chemother- survival and Cox multivariate analyses to evaluate the apy. One of the most important death cause is the prognostic value of MNK1 in EOC. Overexpression and chemoresistance due to consecutive chemotherapy. silencing procedures were performed on OVCAR-5 cells to Therefore, understanding the molecular mechanisms investigate the mechanisms of MNK1 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Clinical and Translational Oncology Springer Journals

Significance of MNK1 in prognostic prediction and chemotherapy development of epithelial ovarian cancer

Loading next page...
 
/lp/springer_journal/significance-of-mnk1-in-prognostic-prediction-and-chemotherapy-jXqgDiLr0B
Publisher
Springer International Publishing
Copyright
Copyright © 2017 by Federación de Sociedades Españolas de Oncología (FESEO)
Subject
Medicine & Public Health; Oncology
ISSN
1699-048X
eISSN
1699-3055
D.O.I.
10.1007/s12094-017-1646-x
Publisher site
See Article on Publisher Site

Abstract

Clin Transl Oncol (2017) 19:1107–1116 DOI 10.1007/s12094-017-1646-x RESEARCH AR TIC L E Significance of MNK1 in prognostic prediction and chemotherapy development of epithelial ovarian cancer 1 2 3 4 5 6 • • • • • S. Hou P. Du P. Wang C. Wang P. Liu H. Liu Received: 21 October 2016 / Accepted: 13 March 2017 / Published online: 22 March 2017 Federacio ´ n de Sociedades Espan ˜ olas de Oncologı ´a (FESEO) 2017 Abstract Methods Immunohistochemical (IHC) staining was used to Background Ovarian cancer is the most lethal gynecologic explore the expression pattern of mitogen-activated protein malignancy worldwide with surgery as the only curative kinase (MAPK)-interacting kinase 1 (MNK1) in tumor treatment. Long-term overall survival (OS) of ovarian tissues from 138 epithelial ovarian cancer (EOC) patients. cancer is far from satisfactory, even though significant Clinicopathological data were subjected to Kaplan–Meier improvement has been made in post-operative chemother- survival and Cox multivariate analyses to evaluate the apy. One of the most important death cause is the prognostic value of MNK1 in EOC. Overexpression and chemoresistance due to consecutive chemotherapy. silencing procedures were performed on OVCAR-5 cells to Therefore, understanding the molecular mechanisms investigate the mechanisms of MNK1

Journal

Clinical and Translational OncologySpringer Journals

Published: Mar 22, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off