Clin Transl Oncol (2017) 19:1107–1116 DOI 10.1007/s12094-017-1646-x RESEARCH AR TIC L E Signiﬁcance of MNK1 in prognostic prediction and chemotherapy development of epithelial ovarian cancer 1 2 3 4 5 6 • • • • • S. Hou P. Du P. Wang C. Wang P. Liu H. Liu Received: 21 October 2016 / Accepted: 13 March 2017 / Published online: 22 March 2017 Federacio ´ n de Sociedades Espan ˜ olas de Oncologı ´a (FESEO) 2017 Abstract Methods Immunohistochemical (IHC) staining was used to Background Ovarian cancer is the most lethal gynecologic explore the expression pattern of mitogen-activated protein malignancy worldwide with surgery as the only curative kinase (MAPK)-interacting kinase 1 (MNK1) in tumor treatment. Long-term overall survival (OS) of ovarian tissues from 138 epithelial ovarian cancer (EOC) patients. cancer is far from satisfactory, even though signiﬁcant Clinicopathological data were subjected to Kaplan–Meier improvement has been made in post-operative chemother- survival and Cox multivariate analyses to evaluate the apy. One of the most important death cause is the prognostic value of MNK1 in EOC. Overexpression and chemoresistance due to consecutive chemotherapy. silencing procedures were performed on OVCAR-5 cells to Therefore, understanding the molecular mechanisms investigate the mechanisms of MNK1
Clinical and Translational Oncology – Springer Journals
Published: Mar 22, 2017
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