Bhavanasi et al. Blood Cancer Journal (2017) 7:636 DOI 10.1038/s41408-017-0003-1 Blood Cancer Journal CORRESPONDENCE Open Access Signaling mechanisms that regulate ex vivo survival of human acute myeloid leukemia initiating cells 1 1,4 2 1 1 1 Dheeraj Bhavanasi ,KwunWah Wen ,Xiaolei Liu , Francois Vergez , Gwenn Danet-Desnoyers , Martin Carroll , 3 1 Jian Huang and Peter S Klein Acute myeloid leukemia (AML) is an aggressive malig- of engrafting immunocompromised mice, identifying a nancy of the hematopoietic system that arises through signaling network that regulates the viability of LICs. clonal expansion of myeloid precursor cells that have As GSK-3 inhibition expands hematopoietic stem and arrested at an early stage of differentiation and ultimately progenitor cells and Gsk3 knockout causes a myelopro- causes death in over 50% of patients. Despite the liferative neoplasm suggestive of AML in mice , we tested aggressive growth characteristics of AML in vivo, AML whether direct inhibition of GSK-3 would enhance the blasts are difﬁcult to culture once removed from the viability of primary AML cells ex vivo. AML cells in cul- patient, suggesting that AML cells depend on signals from ture do not proliferate and typically die over a few days. 1,2 the
Blood Cancer Journal – Springer Journals
Published: Nov 30, 2017
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