Signaling mechanisms that regulate ex vivo survival of human acute myeloid leukemia initiating cells

Signaling mechanisms that regulate ex vivo survival of human acute myeloid leukemia initiating cells Bhavanasi et al. Blood Cancer Journal (2017) 7:636 DOI 10.1038/s41408-017-0003-1 Blood Cancer Journal CORRESPONDENCE Open Access Signaling mechanisms that regulate ex vivo survival of human acute myeloid leukemia initiating cells 1 1,4 2 1 1 1 Dheeraj Bhavanasi ,KwunWah Wen ,Xiaolei Liu , Francois Vergez , Gwenn Danet-Desnoyers , Martin Carroll , 3 1 Jian Huang and Peter S Klein Acute myeloid leukemia (AML) is an aggressive malig- of engrafting immunocompromised mice, identifying a nancy of the hematopoietic system that arises through signaling network that regulates the viability of LICs. clonal expansion of myeloid precursor cells that have As GSK-3 inhibition expands hematopoietic stem and arrested at an early stage of differentiation and ultimately progenitor cells and Gsk3 knockout causes a myelopro- causes death in over 50% of patients. Despite the liferative neoplasm suggestive of AML in mice , we tested aggressive growth characteristics of AML in vivo, AML whether direct inhibition of GSK-3 would enhance the blasts are difficult to culture once removed from the viability of primary AML cells ex vivo. AML cells in cul- patient, suggesting that AML cells depend on signals from ture do not proliferate and typically die over a few days. 1,2 the http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Blood Cancer Journal Springer Journals

Signaling mechanisms that regulate ex vivo survival of human acute myeloid leukemia initiating cells

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Publisher
Nature Publishing Group UK
Copyright
Copyright © 2017 by The Author(s)
Subject
Biomedicine; Biomedicine, general; Cancer Research; Oncology; Hematology
eISSN
2044-5385
D.O.I.
10.1038/s41408-017-0003-1
Publisher site
See Article on Publisher Site

Abstract

Bhavanasi et al. Blood Cancer Journal (2017) 7:636 DOI 10.1038/s41408-017-0003-1 Blood Cancer Journal CORRESPONDENCE Open Access Signaling mechanisms that regulate ex vivo survival of human acute myeloid leukemia initiating cells 1 1,4 2 1 1 1 Dheeraj Bhavanasi ,KwunWah Wen ,Xiaolei Liu , Francois Vergez , Gwenn Danet-Desnoyers , Martin Carroll , 3 1 Jian Huang and Peter S Klein Acute myeloid leukemia (AML) is an aggressive malig- of engrafting immunocompromised mice, identifying a nancy of the hematopoietic system that arises through signaling network that regulates the viability of LICs. clonal expansion of myeloid precursor cells that have As GSK-3 inhibition expands hematopoietic stem and arrested at an early stage of differentiation and ultimately progenitor cells and Gsk3 knockout causes a myelopro- causes death in over 50% of patients. Despite the liferative neoplasm suggestive of AML in mice , we tested aggressive growth characteristics of AML in vivo, AML whether direct inhibition of GSK-3 would enhance the blasts are difficult to culture once removed from the viability of primary AML cells ex vivo. AML cells in cul- patient, suggesting that AML cells depend on signals from ture do not proliferate and typically die over a few days. 1,2 the

Journal

Blood Cancer JournalSpringer Journals

Published: Nov 30, 2017

References

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