Considering the data on the low level of self-organization (self-synchronization) of protein synthesis rhythm in aging, we studied the possible interference of the signaling factors of self-organization, gangliosides and catecholamines, as well as catecholamine reception. Experiments were carried out on primary cultures of rat hepatocytes on slides. Inhibited ganglioside synthesis did not prevent the organization of protein synthesis rhythm by the α-adrenomimetic agent phenylephrine. Upon the blockade of α-receptors by prazosin, the protein synthesis rhythm was observed after the exposure to gangliosides. α-Adrenolytic agents prazosin and benoxathian abolished the synchronizing effect of the β-adrenomimetic isoproterenol. A mixture of α-and β-adrenomimetic agents inhibited the protein synthesis rhythm-organizing effect of noradrenaline. Thus, the signaling molecules of self-organization of protein synthesis function independently via specific receptors.
Russian Journal of Developmental Biology – Springer Journals
Published: Jun 13, 2008
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