Signal Transduction and Activation of Acid Secretion in the Parietal Cell

Signal Transduction and Activation of Acid Secretion in the Parietal Cell J. Membrane Biol. 159, 99–111 (1997) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1997 Topical Review 1 2 T. Urushidani John G. Forte Department of Pharmacology and Toxicology, Faculty of Pharmaceutical Sciences, The University of Tokyo, Hongo, Bunkyo, 113, Japan Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA Received: 7 April 1997 Introduction whereas both M - and CCK -type receptors couple to 3 B non-Gs/Gi systems, probably Gq, to activate phospholi- pase C (PLC) producing inositol 1,4,5-trisphosphate 2+ Parietal Cells Secrete HCl by Translocation and (IP ) and diacylglycerol, with the former releasing Ca Recruitment of the Gastric Proton from intracellular stores, and the latter activating protein + + Pump, H ,K -ATPase kinase C (PKC). This scheme is consistent with the knowledge obtained from many types of cells. The tar- Gastric acid secretion has long fascinated physiologists, get of our interest, as unique events in the parietal cell, is cell biologists and biochemists because of many attrac- focused in this brief review on the downstream reactions 2+ tive riddles in the field. Pure gastric juice, secreted by forming the PKA-, PKC-, or Ca -pathways of activa- the parietal cell, The Journal of Membrane Biology Springer Journals

Signal Transduction and Activation of Acid Secretion in the Parietal Cell

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Copyright © Inc. by 1997 Springer-Verlag New York
Life Sciences; Biochemistry, general; Human Physiology
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