Sex differences in the association of alcohol with cognitive decline and brain pathology in a cohort of octogenarians

Sex differences in the association of alcohol with cognitive decline and brain pathology in a... Rationale The beneficial effects of moderate alcohol may differ in aging men versus women. Objectives Cognitive and functional decline and neuropathology were investigated in a cohort of aging men and women with diverse alcohol histories. Methods Non-demented (Clinical Dementia Rating (CDR) of ≤ 0.5 and a Mini-Mental State Examination (MMSE) score of > 24), autonomously living participants were tracked in longitudinal aging studies to examine self-report and objective tests of rates of decline in a cohort (n = 486) of octogenarians. Neurofibrillary tangles (NFTs; Braak stage) and neuritic plaques (NPs) were staged at autopsy in a subset of participants (n = 149) using current standard neuropathologic diagnostic criteria. Results Moderate drinking men had an attenuated rate of decline compared to rare/never drinkers and women on the MMSE and CDR sum of boxes. In contrast, moderate drinking women had a reduced rate of decline only in the Logical Memory Delayed Recall Test (LMDR) compared to rare/never drinkers and men. Moderate alcohol consumption was associated with a reduction in the incidence of advanced (stages 5–6) Braak NFT stage in men (p < 0.05), with no effect in women. Conclusions In this cohort, men experienced a broader range of beneficial effects associated http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Sex differences in the association of alcohol with cognitive decline and brain pathology in a cohort of octogenarians

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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
D.O.I.
10.1007/s00213-017-4791-6
Publisher site
See Article on Publisher Site

Abstract

Rationale The beneficial effects of moderate alcohol may differ in aging men versus women. Objectives Cognitive and functional decline and neuropathology were investigated in a cohort of aging men and women with diverse alcohol histories. Methods Non-demented (Clinical Dementia Rating (CDR) of ≤ 0.5 and a Mini-Mental State Examination (MMSE) score of > 24), autonomously living participants were tracked in longitudinal aging studies to examine self-report and objective tests of rates of decline in a cohort (n = 486) of octogenarians. Neurofibrillary tangles (NFTs; Braak stage) and neuritic plaques (NPs) were staged at autopsy in a subset of participants (n = 149) using current standard neuropathologic diagnostic criteria. Results Moderate drinking men had an attenuated rate of decline compared to rare/never drinkers and women on the MMSE and CDR sum of boxes. In contrast, moderate drinking women had a reduced rate of decline only in the Logical Memory Delayed Recall Test (LMDR) compared to rare/never drinkers and men. Moderate alcohol consumption was associated with a reduction in the incidence of advanced (stages 5–6) Braak NFT stage in men (p < 0.05), with no effect in women. Conclusions In this cohort, men experienced a broader range of beneficial effects associated

Journal

PsychopharmacologySpringer Journals

Published: Nov 29, 2017

References

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