EDITORIAL Sex difference in cardiac metabolism in nonischemic heart failure: Insight for prognostic value of altered cardiac metabolism a,b a,c Hyung-Jun Im, MD, PhD, and Gi Jeong Cheon, MD, PhD Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Korea Department of Molecular Medicine and Biopharmaceutical Sciences, Graduate School of Convergence Science and Technology, and College of Medicine or College of Pharmacy, Seoul National University, Seoul, Korea Institute of Radiation Medicine, Seoul National University College of Medicine, Seoul, Korea Received Mar 25, 2016; accepted Mar 25, 2016 doi:10.1007/s12350-016-0489-0 that high MBF was associated with the prognosis. See related article, pp. 1226–1235 Although, FA metabolism did not show signiﬁcant association with survival in this study, there has been a hypothesis that decreased FA metabolism in nonis- Heart has the highest metabolic demands than any chemic HF is a maladaptation. In particular, recent other organs. To maintain contractile function of the mouse studies indicate that lower FA metabolism can heart, constant and rapid production of adenosine 5,6 exacerbate nonischemic heart failure. Also, ‘obesity triphosphate (ATP) is needed. Fatty acid (FA) and glu- paradox’ is supporting the hypothesis, which is the cose are the main fuels for production of the
Journal of Nuclear Cardiology – Springer Journals
Published: Apr 6, 2016
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