Sex and strain-related differences in the peripheral blood cell values of inbred mouse strains Benjamin T. Kile, Cammy L. Mason-Garrison, Monica J. Justice Department of Molecular and Human Genetics, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA Received: 13 December 2001 / Accepted: 17 September 2002 With the sequencing of the mouse genome nearing Jackson Laboratory (Bar Harbor, Me.) with the ex- completion, experimental biology is entering a new ception of 129S6/SvEv mice, which were obtained era. The mouse is the primary experimental organ- from Taconic (Germantown, N.Y.), and housed in a ism used to deﬁne mammalian gene function and speciﬁc pathogen-free (SPF) environment. model human disease. Besides the advantages it of- Between the ages of 12 and 16 weeks, 150 llof fers with regard to size, generation time, and evolu- peripheral blood was drawn by retro-orbital punc- tionary proximity to humans, the availability of ture with a Pasteur pipette. Although it has been inbred strains makes the mouse highly amenable to suggested that CBCs obtained via this method genetic investigation. Inbred strains enable re- should not differ signiﬁcantly from counts per- searchers not only to eliminate genetic variation as a formed on samples acquired by
Mammalian Genome – Springer Journals
Published: Jan 1, 2003
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