Sex affects myocardial blood flow and fatty acid substrate metabolism in humans with nonischemic heart failure

Sex affects myocardial blood flow and fatty acid substrate metabolism in humans with nonischemic... ORIGINAL ARTICLE Sex affects myocardial blood flow and fatty acid substrate metabolism in humans with nonischemic heart failure a,b c,d e Ana Kadkhodayan, MD, C. Huie Lin, MD, PhD, Andrew R. Coggan, PhD, e f c Zulfia Kisrieva-Ware, MD, PhD, Kenneth B. Schechtman, PhD, Eric Novak, MS, c c e ´ ´ ´ Susan M. Joseph, MD, Vıctor G. Davila-Roman, MD, Robert J. Gropler, MD, e c Carmen Dence, MS, and Linda R. Peterson, MD, FAHA Department of Medicine, Washington University School of Medicine, St. Louis, MO Cardiovascular Division, Department of Medicine, Mayo Clinic, Rochester, MN Cardiovascular Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO Debakey Cardiovascular Associates, Houston Methodist Hospital, Houston Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO Division of Biostatistics, Washington University School of Medicine, St. Louis, MO Received Dec 27, 2015; accepted Feb 25, 2016 doi:10.1007/s12350-016-0467-6 Background. In animal models of heart failure (HF), myocardial metabolism shifts from high-energy fatty acid (FA) metabolism toward glucose. However, FA (vs glucose) metabolism generates more ATP/mole; thus, FA metabolism may be especially advantageous in HF. Sex modulates myocardial blood flow (MBF) and substrate metabolism in normal humans. Whether sex affects http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Nuclear Cardiology Springer Journals

Sex affects myocardial blood flow and fatty acid substrate metabolism in humans with nonischemic heart failure

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Publisher
Springer US
Copyright
Copyright © 2016 by American Society of Nuclear Cardiology
Subject
Medicine & Public Health; Cardiology; Nuclear Medicine; Imaging / Radiology
ISSN
1071-3581
eISSN
1532-6551
D.O.I.
10.1007/s12350-016-0467-6
Publisher site
See Article on Publisher Site

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