Sestrin family of genes and their role in cancer-related fatigue

Sestrin family of genes and their role in cancer-related fatigue Supportive Care in Cancer (2018) 26:2071–2074 https://doi.org/10.1007/s00520-018-4139-8 COMMENTARY 1 2 3 Velda J. Gonzalez-Mercado & Brooke L. Fridley & Leorey N. Saligan Received: 13 July 2017 / Accepted: 2 March 2018 / Published online: 12 March 2018 Springer-Verlag GmbH Germany, part of Springer Nature 2018 Cancer-related fatigue (CRF) continues to be a prevalent and Association of oxidative stress with cancer distressing symptom experienced by cancer patients and sur- and CRF vivors. CRF is defined by the National Comprehensive Cancer Network as a Bdistressing, persistent, subjective sense Cancer and CRF have both been associated with oxidative of tiredness or exhaustion related to cancer or cancer treatment stress and genomic instability [4–6]. The prominent feature that is not proportional to recent activity and that interferes of cancer cells is their metabolic transformation, which is their with usual functioning [1].^ Although there is currently no reckless acquisition of energy [7]. Briefly, this metabolic optimal management and scant molecular evidence to guide transformation in cancer cells demands a rapid supply of aden- the development of effective CRF therapies, several patho- osine triphosphate (ATP) through the unquenchable consump- physiological mechanisms have been proposed to explain tion of glucose, depleting the mitochondria with available ox- http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Supportive Care in Cancer Springer Journals

Sestrin family of genes and their role in cancer-related fatigue

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Medicine & Public Health; Oncology; Nursing; Nursing Research; Pain Medicine; Rehabilitation Medicine
ISSN
0941-4355
eISSN
1433-7339
DOI
10.1007/s00520-018-4139-8
Publisher site
See Article on Publisher Site

Abstract

Supportive Care in Cancer (2018) 26:2071–2074 https://doi.org/10.1007/s00520-018-4139-8 COMMENTARY 1 2 3 Velda J. Gonzalez-Mercado & Brooke L. Fridley & Leorey N. Saligan Received: 13 July 2017 / Accepted: 2 March 2018 / Published online: 12 March 2018 Springer-Verlag GmbH Germany, part of Springer Nature 2018 Cancer-related fatigue (CRF) continues to be a prevalent and Association of oxidative stress with cancer distressing symptom experienced by cancer patients and sur- and CRF vivors. CRF is defined by the National Comprehensive Cancer Network as a Bdistressing, persistent, subjective sense Cancer and CRF have both been associated with oxidative of tiredness or exhaustion related to cancer or cancer treatment stress and genomic instability [4–6]. The prominent feature that is not proportional to recent activity and that interferes of cancer cells is their metabolic transformation, which is their with usual functioning [1].^ Although there is currently no reckless acquisition of energy [7]. Briefly, this metabolic optimal management and scant molecular evidence to guide transformation in cancer cells demands a rapid supply of aden- the development of effective CRF therapies, several patho- osine triphosphate (ATP) through the unquenchable consump- physiological mechanisms have been proposed to explain tion of glucose, depleting the mitochondria with available ox-

Journal

Supportive Care in Cancer – Springer Journals

Published: Mar 12, 2018

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