Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You and Your Team.

Learn More →

Sestrin family of genes and their role in cancer-related fatigue

Sestrin family of genes and their role in cancer-related fatigue Supportive Care in Cancer (2018) 26:2071–2074 https://doi.org/10.1007/s00520-018-4139-8 COMMENTARY 1 2 3 Velda J. Gonzalez-Mercado & Brooke L. Fridley & Leorey N. Saligan Received: 13 July 2017 / Accepted: 2 March 2018 / Published online: 12 March 2018 Springer-Verlag GmbH Germany, part of Springer Nature 2018 Cancer-related fatigue (CRF) continues to be a prevalent and Association of oxidative stress with cancer distressing symptom experienced by cancer patients and sur- and CRF vivors. CRF is defined by the National Comprehensive Cancer Network as a Bdistressing, persistent, subjective sense Cancer and CRF have both been associated with oxidative of tiredness or exhaustion related to cancer or cancer treatment stress and genomic instability [4–6]. The prominent feature that is not proportional to recent activity and that interferes of cancer cells is their metabolic transformation, which is their with usual functioning [1].^ Although there is currently no reckless acquisition of energy [7]. Briefly, this metabolic optimal management and scant molecular evidence to guide transformation in cancer cells demands a rapid supply of aden- the development of effective CRF therapies, several patho- osine triphosphate (ATP) through the unquenchable consump- physiological mechanisms have been proposed to explain tion of glucose, depleting the mitochondria with available ox- http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Supportive Care in Cancer Springer Journals

Sestrin family of genes and their role in cancer-related fatigue

Download PDF
4 pages
Read Article

Loading next page...
 
/lp/springer_journal/sestrin-family-of-genes-and-their-role-in-cancer-related-fatigue-g4SDXNYGcA
Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Medicine & Public Health; Oncology; Nursing; Nursing Research; Pain Medicine; Rehabilitation Medicine
ISSN
0941-4355
eISSN
1433-7339
DOI
10.1007/s00520-018-4139-8
Publisher site
See Article on Publisher Site

Abstract

Supportive Care in Cancer (2018) 26:2071–2074 https://doi.org/10.1007/s00520-018-4139-8 COMMENTARY 1 2 3 Velda J. Gonzalez-Mercado & Brooke L. Fridley & Leorey N. Saligan Received: 13 July 2017 / Accepted: 2 March 2018 / Published online: 12 March 2018 Springer-Verlag GmbH Germany, part of Springer Nature 2018 Cancer-related fatigue (CRF) continues to be a prevalent and Association of oxidative stress with cancer distressing symptom experienced by cancer patients and sur- and CRF vivors. CRF is defined by the National Comprehensive Cancer Network as a Bdistressing, persistent, subjective sense Cancer and CRF have both been associated with oxidative of tiredness or exhaustion related to cancer or cancer treatment stress and genomic instability [4–6]. The prominent feature that is not proportional to recent activity and that interferes of cancer cells is their metabolic transformation, which is their with usual functioning [1].^ Although there is currently no reckless acquisition of energy [7]. Briefly, this metabolic optimal management and scant molecular evidence to guide transformation in cancer cells demands a rapid supply of aden- the development of effective CRF therapies, several patho- osine triphosphate (ATP) through the unquenchable consump- physiological mechanisms have been proposed to explain tion of glucose, depleting the mitochondria with available ox-

Journal

Supportive Care in Cancer – Springer Journals

Published: Mar 12, 2018

References

  • Pathophysiology of cancer-related fatigue
    Wang, XS
  • Fatigue associated with cancer and its treatment
    Morrow, GR; Andrews, PL; Hickok, JT; Roscoe, JA; Matteson, S
  • Association of mitochondrial dysfunction and fatigue: a review of the literature
    Filler, K; Lyon, D; Bennett, J; McCain, N; Elswick, R; Lukkahatai, N; Saligan, LN
  • Fatigue and oxidative stress in children undergoing leukemia treatment
    Rodgers, C; Sanborn, C; Taylor, O; Gundy, P; Pasvogel, A; Moore, IM; Hockenberry, MJ
  • Sequential molecular changes and dynamic oxidative stress in high-grade serous ovarian carcinogenesis
    Kobayashi, H; Ogawa, K; Kawahara, N; Iwai, K; Niiro, E; Morioka, S; Yamada, Y
  • Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis
    Dong, W; Keibler, MA; Stephanopoulos, G
  • Mitochondrial reactive oxygen species and cancer
    Sullivan, LB; Chandel, NS
  • Ionizing radiation stimulates mitochondrial gene expression and activity
    Gong, B; Chen, Q; Almasan, A
  • FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3
    Hagenbuchner, J; Kuznetsov, A; Hermann, M; Hausott, B; Obexer, P; Ausserlechner, MJ
  • Mitochondria-related gene expression changes are associated with fatigue in patients with nonmetastatic prostate cancer receiving external beam radiation therapy
    Hsiao, CP; Wang, D; Kaushal, A; Saligan, L
  • Differential expression of genes related to mitochondrial biogenesis and bioenergetics in fatigued prostate cancer men receiving external beam radiation therapy
    Hsiao, CP; Wang, D; Kaushal, A; Chen, MK; Saligan, L
  • Sestrins orchestrate cellular metabolism to attenuate aging
    Lee, JH; Budanov, AV; Karin, M
  • Concomitant high expression of ERalpha36, EGFR and HER2 is associated with aggressive behaviors of papillary thyroid carcinomas
    Dai, YJ; Qiu, YB; Jiang, R; Xu, M; Zhao, L; Chen, GG; Liu, ZM
  • Upregulation of alpha-synuclein during localized radiation therapy signals the association of cancer-related fatigue with the activation of inflammatory and neuroprotective pathways
    Saligan, LN; Hsiao, CP; Wang, D; Wang, XM; St John, L; Kaushal, A
  • Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains
    Kim, H; An, S; Ro, SH; Teixeira, F; Park, GJ; Kim, C
  • Sensing the environment through Sestrins: implications for cellular metabolism
    Parmigiani, A; Budanov, AV
  • Sestrin2 expression is a favorable prognostic factor in patients with non-small cell lung cancer
    Chen, KB; Xuan, Y; Shi, WJ; Chi, F; Xing, R; Zeng, YC
  • Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis
    Ro, SH; Xue, X; Ramakrishnan, SK; Cho, CS; Namkoong, S; Jang, I
  • Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells
    Sanli, T; Linher-Melville, K; Tsakiridis, T; Singh, G
  • Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability
    Kopnin, PB; Agapova, LS; Kopnin, BP; Chumakov, PM
  • The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1
    Rhee, SG; Bae, SH
  • Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins
    Woo, HA; Bae, SH; Park, S; Rhee, SG
  • Relative alterations in blood-based levels of Sestrin in Alzheimer’s disease and mild cognitive impairment patients
    Rai, N; Kumar, R; Desai, GR; Venugopalan, G; Shekha, S; Chatterjee, P
  • Antioxidant activity of sestrin 2 controls neuropathic pain after peripheral nerve injury
    Kallenborn-Gerhardt, W; Lu, R; Syhr, KM; Heidler, J; Melchner, H; Geisslinger, G
  • Identifying illness parameters in fatiguing syndromes using classical projection methods
    Broderick, G; Craddock, RC; Whistler, T; Taylor, R; Klimas, N; Unger, ER
  • Expression of Sestrin genes in radiotherapy for prostate cancer and its association with fatigue: a proof-of-concept study
    Gonzalez, VJ; Abbas-Aghababazadeh, F; Fridley, BL; Ghansah, T; Saligan, LN

You’re reading a free preview. Subscribe to read the entire article.

Try 2 weeks free now

DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

or browse the journals available

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$499/year

Save searches from
Google Scholar,
PubMed

Create folders to
organize your research

Export folders, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

Sign up
for free
Start 14 day
Free Trial