Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 14-Day Trial for You or Your Team.

Learn More →

Sestrin family of genes and their role in cancer-related fatigue

Sestrin family of genes and their role in cancer-related fatigue Supportive Care in Cancer (2018) 26:2071–2074 https://doi.org/10.1007/s00520-018-4139-8 COMMENTARY 1 2 3 Velda J. Gonzalez-Mercado & Brooke L. Fridley & Leorey N. Saligan Received: 13 July 2017 / Accepted: 2 March 2018 / Published online: 12 March 2018 Springer-Verlag GmbH Germany, part of Springer Nature 2018 Cancer-related fatigue (CRF) continues to be a prevalent and Association of oxidative stress with cancer distressing symptom experienced by cancer patients and sur- and CRF vivors. CRF is defined by the National Comprehensive Cancer Network as a Bdistressing, persistent, subjective sense Cancer and CRF have both been associated with oxidative of tiredness or exhaustion related to cancer or cancer treatment stress and genomic instability [4–6]. The prominent feature that is not proportional to recent activity and that interferes of cancer cells is their metabolic transformation, which is their with usual functioning [1].^ Although there is currently no reckless acquisition of energy [7]. Briefly, this metabolic optimal management and scant molecular evidence to guide transformation in cancer cells demands a rapid supply of aden- the development of effective CRF therapies, several patho- osine triphosphate (ATP) through the unquenchable consump- physiological mechanisms have been proposed to explain tion of glucose, depleting the mitochondria with available ox- http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Supportive Care in Cancer Springer Journals

Sestrin family of genes and their role in cancer-related fatigue

Download PDF
4 pages

Loading next page...
 
/lp/springer_journal/sestrin-family-of-genes-and-their-role-in-cancer-related-fatigue-g4SDXNYGcA
Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer-Verlag GmbH Germany, part of Springer Nature
Subject
Medicine & Public Health; Oncology; Nursing; Nursing Research; Pain Medicine; Rehabilitation Medicine
ISSN
0941-4355
eISSN
1433-7339
DOI
10.1007/s00520-018-4139-8
Publisher site
See Article on Publisher Site

Abstract

Supportive Care in Cancer (2018) 26:2071–2074 https://doi.org/10.1007/s00520-018-4139-8 COMMENTARY 1 2 3 Velda J. Gonzalez-Mercado & Brooke L. Fridley & Leorey N. Saligan Received: 13 July 2017 / Accepted: 2 March 2018 / Published online: 12 March 2018 Springer-Verlag GmbH Germany, part of Springer Nature 2018 Cancer-related fatigue (CRF) continues to be a prevalent and Association of oxidative stress with cancer distressing symptom experienced by cancer patients and sur- and CRF vivors. CRF is defined by the National Comprehensive Cancer Network as a Bdistressing, persistent, subjective sense Cancer and CRF have both been associated with oxidative of tiredness or exhaustion related to cancer or cancer treatment stress and genomic instability [4–6]. The prominent feature that is not proportional to recent activity and that interferes of cancer cells is their metabolic transformation, which is their with usual functioning [1].^ Although there is currently no reckless acquisition of energy [7]. Briefly, this metabolic optimal management and scant molecular evidence to guide transformation in cancer cells demands a rapid supply of aden- the development of effective CRF therapies, several patho- osine triphosphate (ATP) through the unquenchable consump- physiological mechanisms have been proposed to explain tion of glucose, depleting the mitochondria with available ox-

Journal

Supportive Care in Cancer – Springer Journals

Published: Mar 12, 2018

References

  • Pathophysiology of cancer-related fatigue
    Wang, XS
  • Fatigue associated with cancer and its treatment
    Morrow, GR; Andrews, PL; Hickok, JT; Roscoe, JA; Matteson, S
  • Association of mitochondrial dysfunction and fatigue: a review of the literature
    Filler, K; Lyon, D; Bennett, J; McCain, N; Elswick, R; Lukkahatai, N; Saligan, LN
  • Fatigue and oxidative stress in children undergoing leukemia treatment
    Rodgers, C; Sanborn, C; Taylor, O; Gundy, P; Pasvogel, A; Moore, IM; Hockenberry, MJ
  • Sequential molecular changes and dynamic oxidative stress in high-grade serous ovarian carcinogenesis
    Kobayashi, H; Ogawa, K; Kawahara, N; Iwai, K; Niiro, E; Morioka, S; Yamada, Y
  • Review of metabolic pathways activated in cancer cells as determined through isotopic labeling and network analysis
    Dong, W; Keibler, MA; Stephanopoulos, G
  • Mitochondrial reactive oxygen species and cancer
    Sullivan, LB; Chandel, NS
  • Ionizing radiation stimulates mitochondrial gene expression and activity
    Gong, B; Chen, Q; Almasan, A
  • FOXO3-induced reactive oxygen species are regulated by BCL2L11 (Bim) and SESN3
    Hagenbuchner, J; Kuznetsov, A; Hermann, M; Hausott, B; Obexer, P; Ausserlechner, MJ
  • Mitochondria-related gene expression changes are associated with fatigue in patients with nonmetastatic prostate cancer receiving external beam radiation therapy
    Hsiao, CP; Wang, D; Kaushal, A; Saligan, L
  • Differential expression of genes related to mitochondrial biogenesis and bioenergetics in fatigued prostate cancer men receiving external beam radiation therapy
    Hsiao, CP; Wang, D; Kaushal, A; Chen, MK; Saligan, L
  • Sestrins orchestrate cellular metabolism to attenuate aging
    Lee, JH; Budanov, AV; Karin, M
  • Concomitant high expression of ERalpha36, EGFR and HER2 is associated with aggressive behaviors of papillary thyroid carcinomas
    Dai, YJ; Qiu, YB; Jiang, R; Xu, M; Zhao, L; Chen, GG; Liu, ZM
  • Upregulation of alpha-synuclein during localized radiation therapy signals the association of cancer-related fatigue with the activation of inflammatory and neuroprotective pathways
    Saligan, LN; Hsiao, CP; Wang, D; Wang, XM; St John, L; Kaushal, A
  • Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains
    Kim, H; An, S; Ro, SH; Teixeira, F; Park, GJ; Kim, C
  • Sensing the environment through Sestrins: implications for cellular metabolism
    Parmigiani, A; Budanov, AV
  • Sestrin2 expression is a favorable prognostic factor in patients with non-small cell lung cancer
    Chen, KB; Xuan, Y; Shi, WJ; Chi, F; Xing, R; Zeng, YC
  • Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis
    Ro, SH; Xue, X; Ramakrishnan, SK; Cho, CS; Namkoong, S; Jang, I
  • Sestrin2 modulates AMPK subunit expression and its response to ionizing radiation in breast cancer cells
    Sanli, T; Linher-Melville, K; Tsakiridis, T; Singh, G
  • Repression of sestrin family genes contributes to oncogenic Ras-induced reactive oxygen species up-regulation and genetic instability
    Kopnin, PB; Agapova, LS; Kopnin, BP; Chumakov, PM
  • The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1
    Rhee, SG; Bae, SH
  • Sestrin 2 is not a reductase for cysteine sulfinic acid of peroxiredoxins
    Woo, HA; Bae, SH; Park, S; Rhee, SG
  • Relative alterations in blood-based levels of Sestrin in Alzheimer’s disease and mild cognitive impairment patients
    Rai, N; Kumar, R; Desai, GR; Venugopalan, G; Shekha, S; Chatterjee, P
  • Antioxidant activity of sestrin 2 controls neuropathic pain after peripheral nerve injury
    Kallenborn-Gerhardt, W; Lu, R; Syhr, KM; Heidler, J; Melchner, H; Geisslinger, G
  • Identifying illness parameters in fatiguing syndromes using classical projection methods
    Broderick, G; Craddock, RC; Whistler, T; Taylor, R; Klimas, N; Unger, ER
  • Expression of Sestrin genes in radiotherapy for prostate cancer and its association with fatigue: a proof-of-concept study
    Gonzalez, VJ; Abbas-Aghababazadeh, F; Fridley, BL; Ghansah, T; Saligan, LN