Int Ophthalmol (2018) 38:1095–1101 https://doi.org/10.1007/s10792-017-0565-8 ORIGINAL PAPER Serum bilirubin levels are negatively associated with diabetic retinopathy in patients with type 1 diabetes and normal renal function . . Tomislav Bulum Martina Tomic Lea Duvnjak Received: 7 March 2017 / Accepted: 10 May 2017 / Published online: 18 May 2017 Springer Science+Business Media Dordrecht 2017 Abstract was signiﬁcantly associated with risk of DR in our Introduction Previous studies suggested that total subjects (OR 0.88, CI 0.81–0.96, p = 0.006). serum bilirubin levels are negatively associated with Conclusion These data suggest that serum total diabetic retinopathy (DR) and nephropathy in patients bilirubin levels are independently negatively associ- with diabetes mellitus. The objective of this study was ated with DR in T1DM with normal renal function. to explore the relationship between serum total Prospective studies are needed to conﬁrm whether bilirubin levels and prevalence of DR in patients with lower serum total bilirubin has predictive value for the type 1 diabetes (T1DM) and normal renal function. development of DR in T1DM with normal renal Methods Study included 163 T1DM with normal function. renal function (urinary albumin excretion rate \30 mg/24 h, estimated glomerular ﬁltration rate Keywords Bilirubin Microvascular -1 -2 (eGFR)[60
International Ophthalmology – Springer Journals
Published: May 18, 2017
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