Sertraline

Sertraline Reactions 1680, p307 - 2 Dec 2017 Tic disorder: case report A 78-year-old woman developed tics during treatment with The woman, who was diagnosed with depressive syndrome, was started on sertraline 50 mg/day [route not stated]. One month later, she was found to have involuntary movements identified as an abnormal cervical posture with neck extension, tendency to retrocollis and torticollis to the left, shoulder shrug, eyebrow elevation, throat clearing noises and gasping. She had ability to suppress the movements voluntarily, but with corresponding increase in inner tension. The inner tension was observed with a feeling of a need to do the movements, followed by subsequent explosion of involuntary movements and sounds. One such explosion included that of head jerks with tendency to retrocollis. She exhibited a sensory geste, with which she could improve her cervical posture by placing her hand on the chin, even without any effort to suppress the movements. Clinically, the movement disorder was described as a tic disorder characterized by dystonic, clonic and phonic tics. The woman’s sertraline therapy was discontinued, and she showed a significant improvement in her symptoms. A brain MRI was performed, which showed small subcortical hyperintense T2 lesions with cortical atrophy. For one year, she complained of transient reappearance of tics under stressful situations. Later, the sertraline therapy was reinitiated in view of her husband’s death. One week later, a recurrence of moderate severity tics was observed. The recurrence was observed as mouth opening movements, sniffing and other aforementioned symptoms. All movements found to be suppressible with a subsequent explosion of head jerks, excessive blinking, throat clearing sounds and eyebrow elevation. Therefore, sertraline was stopped, and her symptoms resolved. She was not given sertraline or other selective serotinine reuptake inhibitors for 18 months, with which she found to be tics free. Author comment: "[A] causal relation between sertraline and tics was suspected." "The fact that the patient was exposed a second time to the same drug with tics reappearance strengthens this association." Rua A, et al. Tics Induced by Sertraline: Case Report and Literature Review. Movement Disorders Clinical Practice 1: 243-244, No. 3, Sep 2014. Available from: URL: http://doi.org/10.1002/mdc3.12044 - Portugal 803284581 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Sertraline

Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Publisher
Springer Journals
Copyright
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
D.O.I.
10.1007/s40278-017-39238-4
Publisher site
See Article on Publisher Site

Abstract

Reactions 1680, p307 - 2 Dec 2017 Tic disorder: case report A 78-year-old woman developed tics during treatment with The woman, who was diagnosed with depressive syndrome, was started on sertraline 50 mg/day [route not stated]. One month later, she was found to have involuntary movements identified as an abnormal cervical posture with neck extension, tendency to retrocollis and torticollis to the left, shoulder shrug, eyebrow elevation, throat clearing noises and gasping. She had ability to suppress the movements voluntarily, but with corresponding increase in inner tension. The inner tension was observed with a feeling of a need to do the movements, followed by subsequent explosion of involuntary movements and sounds. One such explosion included that of head jerks with tendency to retrocollis. She exhibited a sensory geste, with which she could improve her cervical posture by placing her hand on the chin, even without any effort to suppress the movements. Clinically, the movement disorder was described as a tic disorder characterized by dystonic, clonic and phonic tics. The woman’s sertraline therapy was discontinued, and she showed a significant improvement in her symptoms. A brain MRI was performed, which showed small subcortical hyperintense T2 lesions with cortical atrophy. For one year, she complained of transient reappearance of tics under stressful situations. Later, the sertraline therapy was reinitiated in view of her husband’s death. One week later, a recurrence of moderate severity tics was observed. The recurrence was observed as mouth opening movements, sniffing and other aforementioned symptoms. All movements found to be suppressible with a subsequent explosion of head jerks, excessive blinking, throat clearing sounds and eyebrow elevation. Therefore, sertraline was stopped, and her symptoms resolved. She was not given sertraline or other selective serotinine reuptake inhibitors for 18 months, with which she found to be tics free. Author comment: "[A] causal relation between sertraline and tics was suspected." "The fact that the patient was exposed a second time to the same drug with tics reappearance strengthens this association." Rua A, et al. Tics Induced by Sertraline: Case Report and Literature Review. Movement Disorders Clinical Practice 1: 243-244, No. 3, Sep 2014. Available from: URL: http://doi.org/10.1002/mdc3.12044 - Portugal 803284581 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680

Journal

Reactions WeeklySpringer Journals

Published: Dec 2, 2017

References

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