Serotonin Transporters – Structure and Function

Serotonin Transporters – Structure and Function J. Membrane Biol. 213, 101–110 (2006) DOI: 10.1007/s00232-006-0878-4 Gary Rudnick Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520-8066, USA Received: 10 November 2006 Introduction to SERT Mechanism Stoichiometry and Mechanism of Transport Serotonin transporter (SERT) selectively transports To understand the mechanism of a transporter like 5-hydroxytryptamine (5-HT) into nerve cells together SERT in detail requires knowledge of four key + ) with Na and Cl and, in the same reaction, trans- properties of the protein: 1) The nature of the binding ports a K ion out of the cell. SERT is a member of site, which determines how the transporter can the SLC6 gene family designated the neurotransmit- selectively transport one substrate and not another. ter sodium symporter (NSS) family 2.A.22 by Saier In cases like SERT, where ions are cotransported (1999). Also in this family are many other trans- with substrate, the relative positioning of substrate porters responsible for reuptake of small neuro- and ion binding sites may be critical for coupling. 2) transmitters, including glycine, c-aminobutyric acid The pathways through which substrate and ions pass (GABA), dopamine (DA), norepinephrine (NE) and in their movement from one side of the membrane The Journal of Membrane Biology Springer Journals

Serotonin Transporters – Structure and Function

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Copyright © 2007 by Springer Science+Business Media, LLC
Life Sciences; Biochemistry, general; Human Physiology
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