Support Care Cancer (2018) 26:1181–1188 https://doi.org/10.1007/s00520-017-3940-0 ORIGINAL ARTICLE Serotonin transporter polymorphism, depressive symptoms, and emotional impulsivity among advanced breast cancer patients 1,2 1,2 3 Youngmee Kim & Charles S. Carver & Joachim F. Hallmayer & 3,4 3 3 3 3 Jamie M. Zeitzer & Oxana Palesh & Eric Neri & Bita Nouriani & David Spiegel Received: 19 April 2017 /Accepted: 23 October 2017 /Published online: 31 October 2017 Springer-Verlag GmbH Germany 2017 Abstract notype to one psychological variable via the other. Results Purpose This study tested a theory linking a marker of low suggest that depressive symptoms, particularly perceived in- serotonergic function to both depression and impulsivity in a terpersonal rejection, may be a pathway linking genotype to sample of advanced breast cancer patients, among whom ele- emotional impulsivity. vated depressive symptoms and difficulty regulating emotions Conclusions Findings provide the first evidence that low se- are commonly reported. rotonergic function contributes to both depression and impul- Methods A total of 95 patients provided blood samples for sivity within a clinically meaningful sample. Furthermore, the serotonin transporter polymorphic region of the gene (5- link of s allele of 5-HTTLPR to emotional impulsivity was HTTLPR) and completed questionnaires that measured de-
Supportive Care in Cancer – Springer Journals
Published: Oct 31, 2017
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