Can J Anesth/J Can Anesth (2017) 64:940–946 DOI 10.1007/s12630-017-0918-9 CASE REP O RTS / CAS E SERIES Serotonergic medications, herbal supplements, and perioperative serotonin syndrome ´ ´ ´ ` Medicaments serotoninergiques, supplements a base de plantes ´ ´ ´ ´ medicinales et syndrome serotoninergique perioperatoire . . . Mary E. Warner, MD Julian Naranjo, DO Emily M. Pollard, MD . . Toby N. Weingarten, MD Mark A. Warner, MD Juraj Sprung, MD, PhD Received: 9 March 2017 / Revised: 10 April 2017 / Accepted: 16 June 2017 / Published online: 30 June 2017 Canadian Anesthesiologists’ Society 2017 Abstract highlights that taking serotonergic agents concomitantly Purpose Perioperative use of serotonergic agents can produce the compounding effect that causes serotonin increases the risk of serotonin syndrome. We describe the syndrome. The delayed presentation of serotonin syndrome occurrence of serotonin syndrome after fentanyl use in two in the patient who received a large dose of midazolam patients taking multiple serotonergic agents. suggests that outpatients taking multiple serotonergic Clinical features Two patients who had been taking drugs who receive benzodiazepines may require longer multiple serotonergic medications or herbal supplements postprocedural monitoring. (one patient taking ﬂuoxetine, turmeric supplement, and acyclovir; the other taking ﬂuoxetine
Canadian Journal of Anesthesia/Journal canadien d'anesthésie – Springer Journals
Published: Jun 30, 2017
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