Epidemiology and clinical outcomes of human cytomegalovirus (HCMV) infection are known to vary between countries and are associated with socio-economic background. So far, few data are available from developing countries, where the overall burden of infectious diseases is frequently higher. Therefore, we analyzed the seroprevalence in a population of 3,740 individuals selected randomly from eastern China, aiming to determine the seroprevalence of and risk factors for HCMV infection. The overall seroprevalence was 48.07%, higher in the socioeconomically developing inland districts than in the developed forelands. The seroprevalence in females (54.60%) was significantly higher than that in males (41.58%) ( P < 0.001). As for profession, peasants (61.54%) and doctors (68.48%) had a higher seropositive rate than members of other professions ( P < 0.0001). A significant association between seroprevalence and increasing age was identified ( P < 0.05). Our study might help to identify appropriate populations on which to focus for future HCMV vaccination.
Archives of Virology – Springer Journals
Published: Apr 1, 2009
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