Seroprevalence and molecular epidemiology of enterovirus 71 in Germany

Seroprevalence and molecular epidemiology of enterovirus 71 in Germany Enterovirus 71 ( EV71) has emerged as a significant pathogen with potential to cause large outbreaks. Because little is known about its seroprevalence and molecular epidemiology in Germany, data for 1997–2007 are presented. Four hundred thirty-six sera from persons aging 10 months to 75 years were tested in a neutralisation test; 63.4% of pre-school children were seronegative, whereas about 75% of adults had antibodies to EV71. Phylogenetic analysis of 28 isolates associated with neurological or cutaneous manifestations showed that isolates belonging to genogroup C1 predominated in 2000–2005, followed by a change to genogroup C2 in 2006 and 2007. This shows the importance of monitoring the diversity of one of the most relevant neurotropic enteroviruses. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Seroprevalence and molecular epidemiology of enterovirus 71 in Germany

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Publisher
Springer Journals
Copyright
Copyright © 2009 by Springer-Verlag
Subject
Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-009-0413-x
Publisher site
See Article on Publisher Site

Abstract

Enterovirus 71 ( EV71) has emerged as a significant pathogen with potential to cause large outbreaks. Because little is known about its seroprevalence and molecular epidemiology in Germany, data for 1997–2007 are presented. Four hundred thirty-six sera from persons aging 10 months to 75 years were tested in a neutralisation test; 63.4% of pre-school children were seronegative, whereas about 75% of adults had antibodies to EV71. Phylogenetic analysis of 28 isolates associated with neurological or cutaneous manifestations showed that isolates belonging to genogroup C1 predominated in 2000–2005, followed by a change to genogroup C2 in 2006 and 2007. This shows the importance of monitoring the diversity of one of the most relevant neurotropic enteroviruses.

Journal

Archives of VirologySpringer Journals

Published: Jul 1, 2009

References

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