Seroprevalence and molecular epidemiology of enterovirus 71 in Germany

Seroprevalence and molecular epidemiology of enterovirus 71 in Germany Enterovirus 71 ( EV71) has emerged as a significant pathogen with potential to cause large outbreaks. Because little is known about its seroprevalence and molecular epidemiology in Germany, data for 1997–2007 are presented. Four hundred thirty-six sera from persons aging 10 months to 75 years were tested in a neutralisation test; 63.4% of pre-school children were seronegative, whereas about 75% of adults had antibodies to EV71. Phylogenetic analysis of 28 isolates associated with neurological or cutaneous manifestations showed that isolates belonging to genogroup C1 predominated in 2000–2005, followed by a change to genogroup C2 in 2006 and 2007. This shows the importance of monitoring the diversity of one of the most relevant neurotropic enteroviruses. Archives of Virology Springer Journals

Seroprevalence and molecular epidemiology of enterovirus 71 in Germany

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Springer Vienna
Copyright © 2009 by Springer-Verlag
Biomedicine; Infectious Diseases; Medical Microbiology ; Virology
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