Sequential combination of docetaxel with a SHP-1 agonist enhanced suppression of p-STAT3 signaling and apoptosis in triple negative breast cancer cells

Sequential combination of docetaxel with a SHP-1 agonist enhanced suppression of p-STAT3... J Mol Med (2017) 95:965–975 DOI 10.1007/s00109-017-1549-x ORIGINAL ARTICLE Sequential combination of docetaxel with a SHP-1 agonist enhanced suppression of p-STAT3 signaling and apoptosis in triple negative breast cancer cells 1,2,3,4 5,6 5 7,8 Chun-Yu Liu & Kuen-Feng Chen & Tzu-I Chao & Pei-Yi Chu & 2,9 1,4 1 10 Chun-Teng Huang & Tzu-Ting Huang & Hsiu-Ping Yang & Wan-Lun Wang & 1 1 1 11 1,2,3 Chia-Han Lee & Ka-Yi Lau & Wen-Chun Tsai & Jung-Chen Su & Chia-Yun Wu & 1,2,3 11 2,4,10 Ming-Huang Chen & Chung-Wai Shiau & Ling-Ming Tseng Received: 9 November 2016 /Revised: 7 May 2017 /Accepted: 19 May 2017 /Published online: 4 June 2017 Springer-Verlag Berlin Heidelberg 2017 Abstract 43 in vitro showed enhanced anti-proliferation and apoptosis Triple negative breast cancer (TNBC) is an aggressive cancer associated with decreased p-STAT3 and decreased STAT3- for which prognosis remains poor. Combination therapy is a downstream effector cyclin D1 in the TNBC cell lines promising strategy for enhancing treatment efficacy. Blockade MDA-MB-231, MDA-MB-468, and HCC-1937. Ectopic ex- of STAT3 signaling may enhance the response of cancer cells pression of STAT3 reduced the increased cytotoxicity induced to conventional chemotherapeutic agents. Here we used a by the combination http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Molecular Medicine Springer Journals

Sequential combination of docetaxel with a SHP-1 agonist enhanced suppression of p-STAT3 signaling and apoptosis in triple negative breast cancer cells

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Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Subject
Biomedicine; Molecular Medicine; Human Genetics; Internal Medicine
ISSN
0946-2716
eISSN
1432-1440
D.O.I.
10.1007/s00109-017-1549-x
Publisher site
See Article on Publisher Site

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