Sequence variation and chromosomal mapping of the murine Cdkn2a tumor suppressor gene

Sequence variation and chromosomal mapping of the murine Cdkn2a tumor suppressor gene Mammalian Genome 8, 65-66 (1997). e//o///e 9 Springer-Verlag New York Inc. 1997 Sequence variation and chromosomal mapping of the murine Cdkn2a tumor suppressor gene C.R. Herzog, M. You Department of Pathology, Medical College of Ohio, Toledo, Ohio 43699, USA Received 23 July 1996 / Accepted: 10 September 1996 Elct 10 60 Twenty-nine mouse strains were examined for sequence variation allele 1 ' of the Cdkn2a (p16 xNK4~) tumor suppressor gene by single-strand allele 2 ........................................... C ....... A.. conformation polymorphism (SSCP) and direct sequence analyses. allele 3 ........................................... C ....... C.. Polymorphisms were observed at nucleotides 53 and 61 of exon lot EII~ 1 36 and at nucleotide 33 of exon 113; the polymorphism of nucleotide alle!e 1 53 of exon let resulted in an amino acid substitution. The mouse allele 2 .................................... strains were distributed into three groups of variants. The poly- allele 3 ............................... C... morphisms in Elet segregated into two groups which cosegregated Fig. 1. Sequence polymorphisms of the Cdkn2a gene. Sequence analysis with those of El13 for all but one strain, the latter of which com- of the alternative transcripts of the Cdkn2a gene revealed complete identity prised the third group. With recombinant inbred strains http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Mammalian Genome Springer Journals

Sequence variation and chromosomal mapping of the murine Cdkn2a tumor suppressor gene

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/lp/springer_journal/sequence-variation-and-chromosomal-mapping-of-the-murine-cdkn2a-tumor-t0ZYYdIXrM
Publisher
Springer-Verlag
Copyright
Copyright © 1997 by Springer-Verlag
Subject
Life Sciences; Cell Biology; Anatomy; Zoology
ISSN
0938-8990
eISSN
1432-1777
D.O.I.
10.1007/s003359900352
Publisher site
See Article on Publisher Site

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