Mammalian Genome 10, 1172–1174 (1999). Incorporating Mouse Genome © Springer-Verlag New York Inc. 1999 Sequence and chromosomal localization of the mouse ortholog of the human olfactory receptor gene 912-93 1 2 3, 1 Sylvie Rouquier, Lisa Stubbs, Isabelle Gaillard-Sanchez, * Dominique Giorgi IGH, CNRS UPR 1142, rue de la Cardonille, 34396 Montpellier cedex 5, France Human Genome Center, Lawrence Livermore National Laboratory, Livermore, California 94550, USA INRA, 2 place Viala, 34000 Montpellier, France Received: 10 June 1999 / Accepted: 3 August 1999 Olfactory receptor gene 912-93 (OR912-93) is a member of the positive phages were isolated. Partial sequencing confirmed that OR multigene family encoding heptahelical transmembrane do- the two clones were identical to the initial mouse 912-93 partial main G protein-coupled olfactory receptors (Buck and Axel 1991; clone. Only one, phage 912-93MB5, was characterized further. Rouquier et al. 1998a, 1998b). In primate hominoids, OR912-93 is The PCR screening was confirmed by Southern blot analysis of unique and contains a single nonsense point mutation in human, restriction enzyme-digested phage DNA (not shown). We sub- whereas the gene is potentially coding in the other hominoids cloned a 2.2-kb BglII-fragment containing the mouse 912-93 se- except gorilla (Rouquier et al. 1998b). OR912-93
Mammalian Genome – Springer Journals
Published: Apr 10, 2014
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