Arch Virol (1997) 142: 157—166
Sequence analysis of the lymphotropic Aleutian disease
S. Schuierer , M. E. Bloom , O. R. Kaaden , and U. Truyen
Institute for Medical Microbiology, Infectious and Epidemic Diseases
University of Munich, Munich, Federal Republic of Germany
Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratory,
National Institute of Allergy and Infectious Disease, Hamilton,
Accepted August 19, 1996
Summary. About 98% of the DNA sequence of the lymphotropic Aleutian
disease parvovirus isolate ADV-SL3 was determined and analysed. The se-
quence revealed that this isolate was a type-1 ADV strain, supporting that the
currently used typing of ADV viruses does not correlate with virulence or
pathogenicity. ADV-SL3 had a very high overall homology of 99.5% to the
prototype strain ADV-G at the DNA level. Comparative sequence analyses with
various ADV isolates of known virulence did not reveal a consensus sequence
that could obviously be responsible for the apparently unique biological proper-
ties of this virus strain.
Aleutian desease of mink is a progressive fatal disease caused by Aleutian disease
parvovirus of mink (ADV) and represents an economically important disease in
countries where mink farming is common. The severity of the disease depends
both on the age of mink at the time of infection and on the genotype of the mink.
The disease in mink kits is an acute pneumonia pathogenically linked to infection
of type-2 pneumocytes and a failure to produce pulmonary surfactant factor .
In adult mink, however, the mechanisms of pathogenicity are not clearly deﬁned.
Mink that are homozygous for the ‘Aleutian gene’ develop a rapid and progres-
sive immune complex-mediated glomerulonephritis and arteritis, and the mink
succumb to the infection within weeks . In non-Aleutian’ mink the disease is
often less dramatic and some mink that will eventually develop the disease
appear clinically unaﬀected for months, or show only mild disease.