J. Membrane Biol. 169, 75–81 (1999) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1999 Topical Review Septins: A Highly Conserved Family of Membrane-Associated GTPases with Functions in Cell Division and Beyond W.S. Trimble Program in Cell Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8 Canada Received: 13 July 1998/Revised: 25 February 1999 Introduction myth, 1976). Screens were carried out in yeast whose replication cycle was by budding (Saccharomyces cer- evisiae) (Hartwell, 1971) or by fission (Schizosaccharo- Septins are members of a highly conserved protein fam- ily first identified in yeast and more recently found in a myces pombe) (Nurse et al., 1976), with the latter organ- wide range of animal cells. Initially, septins were ism predicted to be more analogous to higher eukaryotes thought to function in controlling cytokinesis, as evi- in its division mechanisms. Many of these genes, with denced by their concentration at the mother-bud neck in homologues in both species, have been extensively char- budding yeast, and at the cleavage furrow in dividing acterized and shown to regulate a variety of crucial animal cells. However, recent data suggest that they checkpoints in the cycle, while the precise functions of
The Journal of Membrane Biology – Springer Journals
Published: May 15, 1999
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