Septins: A Highly Conserved Family of Membrane-Associated GTPases with Functions in Cell Division and Beyond

Septins: A Highly Conserved Family of Membrane-Associated GTPases with Functions in Cell Division... J. Membrane Biol. 169, 75–81 (1999) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1999 Topical Review Septins: A Highly Conserved Family of Membrane-Associated GTPases with Functions in Cell Division and Beyond W.S. Trimble Program in Cell Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8 Canada Received: 13 July 1998/Revised: 25 February 1999 Introduction myth, 1976). Screens were carried out in yeast whose replication cycle was by budding (Saccharomyces cer- evisiae) (Hartwell, 1971) or by fission (Schizosaccharo- Septins are members of a highly conserved protein fam- ily first identified in yeast and more recently found in a myces pombe) (Nurse et al., 1976), with the latter organ- wide range of animal cells. Initially, septins were ism predicted to be more analogous to higher eukaryotes thought to function in controlling cytokinesis, as evi- in its division mechanisms. Many of these genes, with denced by their concentration at the mother-bud neck in homologues in both species, have been extensively char- budding yeast, and at the cleavage furrow in dividing acterized and shown to regulate a variety of crucial animal cells. However, recent data suggest that they checkpoints in the cycle, while the precise functions of http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png The Journal of Membrane Biology Springer Journals

Septins: A Highly Conserved Family of Membrane-Associated GTPases with Functions in Cell Division and Beyond

Loading next page...
 
/lp/springer_journal/septins-a-highly-conserved-family-of-membrane-associated-gtpases-with-T5GosuJiLN
Publisher
Springer-Verlag
Copyright
Copyright © Inc. by 1999 Springer-Verlag New York
Subject
Life Sciences; Biochemistry, general; Human Physiology
ISSN
0022-2631
eISSN
1432-1424
D.O.I.
10.1007/s002329900519
Publisher site
See Article on Publisher Site

Abstract

J. Membrane Biol. 169, 75–81 (1999) The Journal of Membrane Biology © Springer-Verlag New York Inc. 1999 Topical Review Septins: A Highly Conserved Family of Membrane-Associated GTPases with Functions in Cell Division and Beyond W.S. Trimble Program in Cell Biology, Hospital for Sick Children, 555 University Avenue, Toronto, Ontario M5G 1X8 Canada Received: 13 July 1998/Revised: 25 February 1999 Introduction myth, 1976). Screens were carried out in yeast whose replication cycle was by budding (Saccharomyces cer- evisiae) (Hartwell, 1971) or by fission (Schizosaccharo- Septins are members of a highly conserved protein fam- ily first identified in yeast and more recently found in a myces pombe) (Nurse et al., 1976), with the latter organ- wide range of animal cells. Initially, septins were ism predicted to be more analogous to higher eukaryotes thought to function in controlling cytokinesis, as evi- in its division mechanisms. Many of these genes, with denced by their concentration at the mother-bud neck in homologues in both species, have been extensively char- budding yeast, and at the cleavage furrow in dividing acterized and shown to regulate a variety of crucial animal cells. However, recent data suggest that they checkpoints in the cycle, while the precise functions of

Journal

The Journal of Membrane BiologySpringer Journals

Published: May 15, 1999

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off