Purpose: A population‑ level description and analysis of sepsis‑ related mortality in China is key to the planning and assessment of interventional strategies. Methods: Retrospective analysis of multiple cause of death (MCOD) recorded in the population‑ based national mor‑ tality surveillance system (NMSS) of China. All sepsis‑ related deaths occurring in 605 disease surveillance points (DSPs) covering 323.8 million population across China were included in our study. Age‑ standardized mortality and national estimate of sepsis‑ related deaths were estimated using the census population in 2010 and 2015, respectively. Results: In 2015, a total of 1,937,299 deaths occurring in any of the 605 DSPs and standardized sepsis‑ related mortal‑ ity rate was 66.7 (95% confidence interval [CI] 66.4–67.0) deaths per 100,000 population. This produced a national estimate of 1,025,997 sepsis‑ related deaths. Sepsis‑ related mortality rates exhibited significant geographic variation. In multilevel analysis, male sex (rate ratio [RR] 1.582, 95% CI 1.570–1.595), increasing age (RR 1.914 for 5‑ year group, 95% CI 1.910–1.917), and presence of comorbidity (RR 2.316, 95% CI 2.298–2.335) were independently associated with increased sepsis‑ related mortality. Higher disposable income (RR 0.717 for the fourth interquartile range vs. the first interquartile range, 95% CI 0.515–0.978) and mean
Intensive Care Medicine – Springer Journals
Published: May 30, 2018
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