Sentinel node biopsy for malignant melanoma – technical details and clinical results in 259 patients

Sentinel node biopsy for malignant melanoma – technical details and clinical results in 259... The purpose of this paper was to present our 4-year experience with sentinel node biopsy in the treatment of malignant melanoma. We will present technical details that influence the efficacy of the procedure and discuss the clinical, therapeutic and prognostic advantages of this technique. A total of 259 consecutive patients with primary skin melanoma (T2–3 N0 M0) underwent sentinel node biopsy between March 1996 and May 2000. All patients underwent previous excisional biopsy of the primary lesion and clinical and radiographic examination to exclude lymphatic or systemic macroscopic spread of the disease. Preoperative lymphoscintigraphy (99mTc-nanocoll) was routinely performed in the last 184 patients. Intraoperative detection of the sentinel node was performed by perilesional, intradermal injection of blue dye associated with a gamma probe (Neoprobe 2000) in the last 141 patients. For each anatomical site of dissection (inguinal, axillary, head and neck), detection rates with or without gamma probe were compared, focusing on the main reasons for failure. Sentinel nodes, serially sectioned, were all hematoxylin-eosin and immunohistochemically stained. All patients positive for micrometastasis underwent radical lymphadenectomy. Comparative analysis was performed between the incidence of metastasis in sentinel and non-sentinel nodes, according to the clinical stage of the disease. The overall detection rate of sentinel nodes was 96%. Relevant differences were found according to the site of dissection and the use of a gamma probe. The gamma probe makes the procedure more effective, less invasive, and less expensive. Timing and accuracy of the preoperative lymphoscintigraphy are basic steps in the procedure. The overall incidence of positive sentinel node was 14.6% with differences correlated with thickness of primary lesion (0.75–1.5 mm: 7.3%; 1.5–3 mm: 14.9%; 3–4 mm: 30.5%). Metastasis in other non- sentinel nodes was found only with primary tumor thickness exceeding 2 mm. Correlation between sentinel node metastasis and prognosis as well as adjuvant therapy will be discussed. Sentinel node biopsy is a procedure requiring a multidisciplinary approach (surgery, nuclear medicine, and pathology). A specific learning phase (>30 patients) is recommended for reliable results. An improvement in survival rates by sentinel node biopsy has not yet been demonstrated, but this more accurate N-staging procedure offers clear advantages in terms of the patient’s quality of life, prognosis, and indication for adjuvant therapy. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png European Journal of Plastic Surgery Springer Journals

Sentinel node biopsy for malignant melanoma – technical details and clinical results in 259 patients

Loading next page...
 
/lp/springer_journal/sentinel-node-biopsy-for-malignant-melanoma-technical-details-and-C6yuN8hwGE
Publisher
Springer-Verlag
Copyright
Copyright © 2000 by Springer-Verlag Berlin Heidelberg
Subject
Medicine & Public Health; Plastic Surgery
ISSN
0930-343X
eISSN
1435-0130
D.O.I.
10.1007/s002380000206
Publisher site
See Article on Publisher Site

There are no references for this article.

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 12 million articles from more than
10,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Unlimited reading

Read as many articles as you need. Full articles with original layout, charts and figures. Read online, from anywhere.

Stay up to date

Keep up with your field with Personalized Recommendations and Follow Journals to get automatic updates.

Organize your research

It’s easy to organize your research with our built-in tools.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

Monthly Plan

  • Read unlimited articles
  • Personalized recommendations
  • No expiration
  • Print 20 pages per month
  • 20% off on PDF purchases
  • Organize your research
  • Get updates on your journals and topic searches

$49/month

Start Free Trial

14-day Free Trial

Best Deal — 39% off

Annual Plan

  • All the features of the Professional Plan, but for 39% off!
  • Billed annually
  • No expiration
  • For the normal price of 10 articles elsewhere, you get one full year of unlimited access to articles.

$588

$360/year

billed annually
Start Free Trial

14-day Free Trial