Semi-quantitative analysis of salivary gland scintigraphy in Sjögren’s syndrome diagnosis: a first-line tool

Semi-quantitative analysis of salivary gland scintigraphy in Sjögren’s syndrome diagnosis: a... Objective The aim of this study was the assessment of semi- lower in pSS patients compared to those in non-pSS quantified salivary gland dynamic scintigraphy (SGdS) pa- (p < 0.001). ROC curve showed significantly large AUC for rameters independently and in an integrated way in order to both the parameters (p <0.05). predict primary Sjögren’s syndrome (pSS). Parotid UP and submandibular EF, assessed by Materials and methods Forty-six consecutive patients (41 fe- univariated and multivariate logistic regression, showed males; age 61 ± 11 years) with sicca syndrome were studied a significant and independent correlation with pSS diag- by SGdS after injection of 200 MBq of pertechnetate. In six- nosis (p value <0.05). No correlation was found between teen patients, pSS was diagnosed, according to American- SGdS semi-quantitative parameters and ESSDAI. The European Consensus Group criteria (AECGc). proposed nomogram accuracy was 87%. Semi-quantitative parameters (uptake (UP) and excretion Conclusion SGdS is an accurate and reproducible tool for the fraction (EF)) were obtained for each gland. ROC curves were diagnosis of pSS. ESSDAI was not shown to be correlated used to determine the best cut-off value. The area under the with SGdS data. Clinical relevance SGdS should be the first-line imaging Clinical Oral Investigations Springer Journals

Semi-quantitative analysis of salivary gland scintigraphy in Sjögren’s syndrome diagnosis: a first-line tool

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Springer Berlin Heidelberg
Copyright © 2017 by Springer-Verlag Berlin Heidelberg
Dentistry; Dentistry
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