ISSN 1070-4272, Russian Journal of Applied Chemistry, 2015, Vol. 88, No. 5, pp. 861−865. © Pleiades Publishing, Ltd., 2015.
Original Russian Text © M.V. Bazunova, V.G. Shamratova, L.A. Sharafutdinova, D.R. Valiev, V.V. Chernova, E.I. Kulish, 2015, published in Zhurnal Prikladnoi
Khimii, 2015, Vol. 88, No. 5, pp. 821−825.
Self-Organizing Hybrid Systems Chitosan
Succinamide–Silver Iodide Sol and Their Hemocompatibility
M. V. Bazunova, V. G. Shamratova, L. A. Sharafutdinova, D. R. Valiev,
V. V. Chernova, and E. I. Kulish
Bashkir State University, ul. Kommunisticheskaya 19, Ufa, Bashkortostan, 450076 Russia
Received March 23, 2015
Abstract— Self-organization of a water-soluble chitosan derivative, chitosan succinamide sodium salt, in the
presence of colloidal particles of silver iodide sol was studied. The polymer–colloid disperse system formed is
essentially a polymer–inorganic nanocomposite in which chitosan succinamide macromolecules act as a stabi-
lizer of inorganic nanoparticles. The reaction of the system components leads to the formation of a network of
intermolecular contacts whose nodes are colloidal particles of silver iodide sol, on which the polymer chains are
speciﬁ cally adsorbed. The chitosan succinamide–silver iodide sol ultradisperse systems exert a stabilizing effect
on erythrocyte membranes.
The capability of macromolecules for self-assembly
ﬁ nds increasing use for preparation of polymeric hybrid
nanocomposite materials. By the self-assembly is meant
spontaneous intermolecular association via noncovalent
bonds (electrostatic, hydrogen, etc.), resulting in
formation of supramolecular structures of size from
10 nm to 10 μm . An example of the implementation
of this approach is introduction of multicharged ions,
surfactant micelles, or inorganic colloidal particles into
polyelectrolyte solutions [2–5].
Combination of unique properties of hydrophobic
colloidal inorganic particles with the set of properties of
a hydrophilic polymeric matrix often gives rise to new
characteristics and properties of materials. Such hybrid
composites can be used both in the form of solid bulk
materials and ﬁ lms  and in the form of solutions.
They can be successfully used for numerous purposes,
in particular, in cosmetology and medicine. For example,
such systems can be used for targeted delivery of oil-
soluble drugs encapsulated into the core of a polymeric
container. In this case, hydrophobic nano- and microsized
inorganic particles play the role of a core [7, 8].
In the case of biomedical use of polymeric self-
organizing hybrid systems, substances exhibiting, among
other things, antiseptic properties, e.g., silver or silver
oxide particles, as well as insoluble silver salts, can be
taken as nanosized inorganic particles [9–11].
This study deals with the self-organization of a
water-soluble chitosan derivative, chitosan succinamide
sodium salt (CSSS), in the presence of colloidal particles
of silver iodide sol. The choice of the polymer is
governed by the set of its unique properties including the
antimicrobial activity, compatibility with body tissues,
and biodegradability [12, 13]. The choice of the silver
iodide sol is governed by its bactericidal properties .
As investigation objects we used CSSS with MM =
207 kDa and intrinsic viscosity [η]= 3.60 dL g
(Technical Specification) 9284-027-11734126–08],
produced by ZAO Bioprogress (Shchelkovo, Russia).
The degree of substitution of CSSS with respect to amino
groups is 75%. The degree of deacetylation of the initial
chitosan sample from which CSSS was prepared is 82%.
Double-distilled water was used as solvent. Positively
charged micelles of the AgI sol were prepared by the