Access the full text.
Sign up today, get DeepDyve free for 14 days.
M. Ågren, T. Andersen, U. Mirastschijski, I. Syk, C. Schiødt, V. Surve, J. Lindebjerg, J. Delaisse (2006)
Action of matrix metalloproteinases at restricted sites in colon anastomosis repair: an immunohistochemical and biochemical study.Surgery, 140 1
M. Rehn, P. Krarup, L. Christensen, J. Seidelin, M. Ågren, I. Syk (2015)
GM6001 Increases Anastomotic Leakage following Colonic Obstruction Possibly by Impeding Epithelialization.Surgical infections, 16 6
J. Hutchinson, G. Tierney, S. Parsons, T. Davis (1998)
Dupuytren's disease and frozen shoulder induced by treatment with a matrix metalloproteinase inhibitor.The Journal of bone and joint surgery. British volume, 80 5
B. Oxlund, G. Ørtoft, A. Brüel, C. Danielsen, P. Bor, H. Oxlund, N. Uldbjerg (2010)
Collagen concentration and biomechanical properties of samples from the lower uterine cervix in relation to age and parity in non-pregnant womenReproductive Biology and Endocrinology : RB&E, 8
S. Fichtner-Feigl, I. Fuss, Cheryl Young, Tomohiro Watanabe, E. Geissler, H. Schlitt, A. Kitani, W. Strober (2007)
Induction of IL-13 Triggers TGF-β1-Dependent Tissue Fibrosis in Chronic 2,4,6-Trinitrobenzene Sulfonic Acid ColitisThe Journal of Immunology, 178
C. Kilkenny, W. Browne, I. Cuthill, Michael Emerson, D. Altman (2012)
Improving Bioscience Research Reporting: The ARRIVE Guidelines for Reporting Animal Research †Animals : an Open Access Journal from MDPI, 4
G. Deans, Z. Krukowski, S. Irwin (1994)
Malignant obstruction of the left colonBritish Journal of Surgery, 81
Benjamin Shogan, N. Belogortseva, Preston Luong, A. Zaborin, S. Lax, Cindy Bethel, M. Ward, J. Muldoon, Mark Singer, G. An, K. Umanskiy, V. Konda, Baddr Shakhsheer, James Luo, R. Klabbers, L. Hancock, J. Gilbert, O. Zaborina, J. Alverdy (2015)
Collagen degradation and MMP9 activation by Enterococcus faecalis contribute to intestinal anastomotic leakScience Translational Medicine, 7
M. Ågren, T. Andersen, L. Andersen, C. Schiødt, V. Surve, T. Andreassen, J. Risteli, L. Franzén, J. Delaisse, A. Heegaard, L. Jørgensen (2011)
Nonselective matrix metalloproteinase but not tumor necrosis factor-α inhibition effectively preserves the early critical colon anastomotic integrityInternational Journal of Colorectal Disease, 26
G. Cameron, I. Alberts, J. Laing, T. Wess (2002)
Structure of type I and type III heterotypic collagen fibrils: an X-ray diffraction study.Journal of structural biology, 137 1-2
Anders Törnqvist, P. Blomquist, H. Jiborn, B. Zederfeldt (1990)
Anastomotic healing after resection of left-colon stenosis: Effect on collagen metabolism and anastomotic strengthDiseases of the Colon & Rectum, 33
R. Jex, J. Heerden, B. Wolff, R. Ready, D. Ilstrup (1987)
Gastrointestinal Anastomoses Factors Affecting Early ComplicationsAnnals of Surgery, 206
A Törnqvist, P Blomquist, H Jiborn, B Zederfeldt (1990)
Anastomotic healing after resection of left-colon stenosis: effect on collagen metabolism and anastomotic strength. An experimental study in the ratDis Colon Rectum, 33
YY Li, AM Feldman (2001)
Matrix metalloproteinases in the progression of heart failure: potential therapeutic implicationsDrugs, 61
R. Mittal, Amit Patel, Luca Debs, Desiree Nguyen, Kunal Patel, M. Grati, Jeenu Mittal, D. Yan, P. Chapagain, X. Liu (2016)
Intricate Functions of Matrix Metalloproteinases in Physiological and Pathological ConditionsJournal of Cellular Physiology, 231
D. Hayden, C. Forsyth, A. Keshavarzian (2011)
The role of matrix metalloproteinases in intestinal epithelial wound healing during normal and inflammatory states.The Journal of surgical research, 168 2
I. Syk, Magnus Ågren, D. Adawi, Bengt Jeppsson (2001)
Inhibition of matrix metalloproteinases enhances breaking strength of colonic anastomoses in an experimental modelBritish Journal of Surgery, 88
R. Gibson, Ysabella Sebille, H. Wardill, Anthony Wignall, Joseph Shirren, Imogen Ball, Nicole Williams, Kiara Wanner, J. Bowen (2019)
Selective MMP Inhibition, Using AZD3342, to Reduce Gastrointestinal Toxicity and Enhance Chemoefficacy in a Rat ModelChemotherapy, 63
M. Björnsson, A. Havemose-Poulsen, K. Stoltze, P. Holmstrup (2004)
Influence of the matrix metalloproteinase inhibitor batimastat (BB-94) on periodontal bone destruction in Sprague-Dawley rats.Journal of periodontal research, 39 4
I. Syk, U. Mirastschijski, B. Jeppsson, M. Ågren (2003)
Experimental Colonic Obstruction Increases Collagen Degradation by Matrix Metalloproteinases in the Bowel WallDiseases of the Colon & Rectum, 46
Y. Li, T. Kadokami, Ping Wang, C. McTiernan, A. Feldman (2002)
MMP inhibition modulates TNF-alpha transgenic mouse phenotype early in the development of heart failure.American journal of physiology. Heart and circulatory physiology, 282 3
Y. Li, A. Feldman (2012)
Matrix Metalloproteinases in the Progression of Heart FailureDrugs, 61
P. Krarup, M. Eld, K. Heinemeier, L. Jørgensen, M. Hansen, M. Ågren (2013)
Expression and inhibition of matrix metalloproteinase (MMP)-8, MMP-9 and MMP-12 in early colonic anastomotic repairInternational Journal of Colorectal Disease, 28
N. Rahbari, J. Weitz, W. Hohenberger, R. Heald, B. Moran, A. Ulrich, T. Holm, W. Wong, E. Tiret, Y. Moriya, S. Laurberg, M. Dulk, C. Velde, M. Büchler (2010)
Definition and grading of anastomotic leakage following anterior resection of the rectum: a proposal by the International Study Group of Rectal Cancer.Surgery, 147 3
R. Renkiewicz, Luping Qiu, C. Lesch, Xin-Xin Sun, R. Devalaraja, Theresa Cody, E. Kaldjian, H. Welgus, V. Baragi (2003)
Broad-spectrum matrix metalloproteinase inhibitor marimastat-induced musculoskeletal side effects in rats.Arthritis and rheumatism, 48 6
I. Hingh, M. Siemonsma, B. Man, R. Lomme, T. Hendriks (2002)
The matrix metalloproteinase inhibitor BB-94 improves the strength of intestinal anastomoses in the ratInternational Journal of Colorectal Disease, 17
R. Golub, Golub Rw, R. Cantu, H. Stein (1997)
A multivariate analysis of factors contributing to leakage of intestinal anastomoses.Journal of the American College of Surgeons, 184 4
WS Halsted (1887)
Circular suture of the intestine—an experimental studyAm J Med Sci, 188
P. Krarup, M. Rehn, Janna Sand-Dejmek, Roy Ehrnström, M. Ågren, I. Syk (2013)
Rapid morphological changes and loss of collagen following experimental acute colonic obstructionInternational Journal of Colorectal Disease, 28
J. Hutchinson, G. Tierney, S. Parsons, T. Davis (1998)
Dupuytren's disease and frozen shoulder induced by treatment with a matrix metalloproteinase inhibitorJournal of Bone and Joint Surgery, American Volume, 80
Mari Oines, P. Krarup, L. Jørgensen, M. Ågren (2014)
Pharmacological interventions for improved colonic anastomotic healing: a meta-analysis.World journal of gastroenterology, 20 35
G. Galanopoulos, D. Raptis, M. Pramateftakis, I. Mantzoros, I. Kanellos, Charalambos Lazarides (2014)
The effects of iloprost on colonic anastomotic healing in rats under obstructive ileus conditions.The Journal of surgical research, 189 1
C Kilkenny, WJ Browne, IC Cuthill, M Emerson, DG Altman (2010)
Improving bioscience research reporting: the ARRIVE guidelines for reporting animal researchPLoS Biol, 8
L. Durães, Igor Farias, P. Morais, P. Oliveira, Florêncio Neto, Ruy Júnior, O. Féres, J. Sousa (2013)
The effect of carbon dioxide pneumoperitoneum on the healing colonic anastomosis in rats.Acta cirurgica brasileira, 28 9
R. Neuman, M. Logan (1950)
The determination of collagen and elastin in tissues.The Journal of biological chemistry, 186 2
(1984)
Classic articles in colonic and rectal surgery. William Stewart Halsted, 1852-1922. Circular suture of the intestine--an experimental study.Diseases of the colon and rectum, 27 9
M. Kjaer, Hrefna Kristjánsdóttir, L. Andersen, A. Heegaard, M. Ågren, L. Jørgensen (2018)
The effect of gender on early colonic anastomotic wound healingInternational Journal of Colorectal Disease, 33
Malene Nerstrøm, P. Krarup, L. Jørgensen, M. Ågren (2016)
Therapeutic improvement of colonic anastomotic healing under complicated conditions: A systematic review.World journal of gastrointestinal surgery, 8 5
C. Jacobi, J. Ordemann, Zieren Hu, H. Volk, A. Bauhofer, E. Halle, J. Müller (1998)
Increased systemic inflammation after laparotomy vs laparoscopy in an animal model of peritonitis.Archives of surgery, 133 3
T. Kiyama, M. Onda, A. Tokunaga, D. Efron, A. Barbul (2001)
Effect of matrix metalloproteinase inhibition on colonic anastomotic healing in ratsJournal of Gastrointestinal Surgery, 5
R Golub (1997)
364J Am Coll Surg, 184
Purpose Colonic obstruction causes loss of collagen and im- AZD3342 but decreased by 25% (P = 0.023) in the vehicle pairment of anastomotic integrity by matrix metalloprotein- group. The anastomotic breaking strength of AZD3342- ases (MMPs). Unexpectedly, pharmacological MMP inhibi- treated rats was 44% higher (P = 0.008) than the vehicle- tion increased anastomotic leakage (AL) in obstructed colon treated rats. Furthermore, the AL rate was reduced possibly due to the non-selective nature of these compounds (P = 0.037) with AZD3342 compared with vehicle treatment. and the experimental model applied. We therefore studied the AZD3342 treatment influenced neither the total or insoluble effects of selective MMP inhibition on the healing of anasto- collagen concentrations nor the degree of fragmentation of the moses in colon obstructed by a novel laparoscopic technique. soluble collagen triple helices. Methods Left colonwas obstructedin38maleSprague- Conclusion Selective MMP inhibition increased anastomotic Dawley rats (226–284 g). After 12 h, stenoses were resected breaking strength and reduced AL after resection of colonic and end-to-end anastomoses constructed. Baseline breaking obstruction. strength was determined in 6 animals on day 0. The remaining . . 32 rats were randomized to daily treatment with the selective Keywords Anastomosis Anastomotic leak Breaking .
International Journal of Colorectal Disease – Springer Journals
Published: Jul 17, 2017
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.