Selective matrix metalloproteinase inhibition increases breaking strength and reduces anastomotic leakage in experimentally obstructed colon

Selective matrix metalloproteinase inhibition increases breaking strength and reduces anastomotic... Purpose Colonic obstruction causes loss of collagen and im- AZD3342 but decreased by 25% (P = 0.023) in the vehicle pairment of anastomotic integrity by matrix metalloprotein- group. The anastomotic breaking strength of AZD3342- ases (MMPs). Unexpectedly, pharmacological MMP inhibi- treated rats was 44% higher (P = 0.008) than the vehicle- tion increased anastomotic leakage (AL) in obstructed colon treated rats. Furthermore, the AL rate was reduced possibly due to the non-selective nature of these compounds (P = 0.037) with AZD3342 compared with vehicle treatment. and the experimental model applied. We therefore studied the AZD3342 treatment influenced neither the total or insoluble effects of selective MMP inhibition on the healing of anasto- collagen concentrations nor the degree of fragmentation of the moses in colon obstructed by a novel laparoscopic technique. soluble collagen triple helices. Methods Left colonwas obstructedin38maleSprague- Conclusion Selective MMP inhibition increased anastomotic Dawley rats (226–284 g). After 12 h, stenoses were resected breaking strength and reduced AL after resection of colonic and end-to-end anastomoses constructed. Baseline breaking obstruction. strength was determined in 6 animals on day 0. The remaining . . 32 rats were randomized to daily treatment with the selective Keywords Anastomosis Anastomotic leak Breaking . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Colorectal Disease Springer Journals

Selective matrix metalloproteinase inhibition increases breaking strength and reduces anastomotic leakage in experimentally obstructed colon

Loading next page...
 
/lp/springer_journal/selective-matrix-metalloproteinase-inhibition-increases-breaking-0wj6hPEOQU
Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Medicine & Public Health; Surgery; Internal Medicine; Gastroenterology; Hepatology; Proctology
ISSN
0179-1958
eISSN
1432-1262
D.O.I.
10.1007/s00384-017-2857-x
Publisher site
See Article on Publisher Site

Abstract

Purpose Colonic obstruction causes loss of collagen and im- AZD3342 but decreased by 25% (P = 0.023) in the vehicle pairment of anastomotic integrity by matrix metalloprotein- group. The anastomotic breaking strength of AZD3342- ases (MMPs). Unexpectedly, pharmacological MMP inhibi- treated rats was 44% higher (P = 0.008) than the vehicle- tion increased anastomotic leakage (AL) in obstructed colon treated rats. Furthermore, the AL rate was reduced possibly due to the non-selective nature of these compounds (P = 0.037) with AZD3342 compared with vehicle treatment. and the experimental model applied. We therefore studied the AZD3342 treatment influenced neither the total or insoluble effects of selective MMP inhibition on the healing of anasto- collagen concentrations nor the degree of fragmentation of the moses in colon obstructed by a novel laparoscopic technique. soluble collagen triple helices. Methods Left colonwas obstructedin38maleSprague- Conclusion Selective MMP inhibition increased anastomotic Dawley rats (226–284 g). After 12 h, stenoses were resected breaking strength and reduced AL after resection of colonic and end-to-end anastomoses constructed. Baseline breaking obstruction. strength was determined in 6 animals on day 0. The remaining . . 32 rats were randomized to daily treatment with the selective Keywords Anastomosis Anastomotic leak Breaking .

Journal

International Journal of Colorectal DiseaseSpringer Journals

Published: Jul 17, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off