Psychopharmacology (2017) 234:2727–2735 DOI 10.1007/s00213-017-4668-8 ORIGINAL INVESTIGATION Selective enhancement of NMDA receptor-mediated locomotor hyperactivity by male sex hormones in mice 1,2,3,4 1,5 1 1 Maarten van den Buuse & Jac Kee Low & Perrin Kwek & Sally Martin & 1,6 Andrea Gogos Received: 4 October 2016 /Accepted: 29 May 2017 /Published online: 3 July 2017 Springer-Verlag GmbH Germany 2017 Abstract prepulse inhibition of startle (PPI) was similar in intact and Rationale Altered glutamate NMDA receptor function is im- castrated male mice and in ovariectomized (OVX) female plicated in schizophrenia, and gender differences have been mice. In contrast, there was no effect of MK-801 on PPI in demonstrated in this illness. intact female mice. Forebrain NMDA receptor density, as Objectives This study aimed to investigate the interaction of measured with [ H]MK-801 autoradiography, was signifi- gonadal hormones with NMDA receptor-mediated locomotor cantly higher in male than in female mice but was not signif- hyperactivity and PPI disruption in mice. icantly altered by either castration or OVX. Results The effect of 0.25 mg/kg of MK-801 on locomotor Conclusions These results suggest that male sex hormones activity was greater in male mice than in female mice. enhance the effect of NMDA receptor
Psychopharmacology – Springer Journals
Published: Jul 3, 2017
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