Selective enhancement of NMDA receptor-mediated locomotor hyperactivity by male sex hormones in mice

Selective enhancement of NMDA receptor-mediated locomotor hyperactivity by male sex hormones in mice Psychopharmacology (2017) 234:2727–2735 DOI 10.1007/s00213-017-4668-8 ORIGINAL INVESTIGATION Selective enhancement of NMDA receptor-mediated locomotor hyperactivity by male sex hormones in mice 1,2,3,4 1,5 1 1 Maarten van den Buuse & Jac Kee Low & Perrin Kwek & Sally Martin & 1,6 Andrea Gogos Received: 4 October 2016 /Accepted: 29 May 2017 /Published online: 3 July 2017 Springer-Verlag GmbH Germany 2017 Abstract prepulse inhibition of startle (PPI) was similar in intact and Rationale Altered glutamate NMDA receptor function is im- castrated male mice and in ovariectomized (OVX) female plicated in schizophrenia, and gender differences have been mice. In contrast, there was no effect of MK-801 on PPI in demonstrated in this illness. intact female mice. Forebrain NMDA receptor density, as Objectives This study aimed to investigate the interaction of measured with [ H]MK-801 autoradiography, was signifi- gonadal hormones with NMDA receptor-mediated locomotor cantly higher in male than in female mice but was not signif- hyperactivity and PPI disruption in mice. icantly altered by either castration or OVX. Results The effect of 0.25 mg/kg of MK-801 on locomotor Conclusions These results suggest that male sex hormones activity was greater in male mice than in female mice. enhance the effect of NMDA receptor http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Psychopharmacology Springer Journals

Selective enhancement of NMDA receptor-mediated locomotor hyperactivity by male sex hormones in mice

Loading next page...
 
/lp/springer_journal/selective-enhancement-of-nmda-receptor-mediated-locomotor-c0Iu0urnOf
Publisher
Springer Berlin Heidelberg
Copyright
Copyright © 2017 by Springer-Verlag GmbH Germany
Subject
Biomedicine; Neurosciences; Pharmacology/Toxicology; Psychiatry
ISSN
0033-3158
eISSN
1432-2072
D.O.I.
10.1007/s00213-017-4668-8
Publisher site
See Article on Publisher Site

Abstract

Psychopharmacology (2017) 234:2727–2735 DOI 10.1007/s00213-017-4668-8 ORIGINAL INVESTIGATION Selective enhancement of NMDA receptor-mediated locomotor hyperactivity by male sex hormones in mice 1,2,3,4 1,5 1 1 Maarten van den Buuse & Jac Kee Low & Perrin Kwek & Sally Martin & 1,6 Andrea Gogos Received: 4 October 2016 /Accepted: 29 May 2017 /Published online: 3 July 2017 Springer-Verlag GmbH Germany 2017 Abstract prepulse inhibition of startle (PPI) was similar in intact and Rationale Altered glutamate NMDA receptor function is im- castrated male mice and in ovariectomized (OVX) female plicated in schizophrenia, and gender differences have been mice. In contrast, there was no effect of MK-801 on PPI in demonstrated in this illness. intact female mice. Forebrain NMDA receptor density, as Objectives This study aimed to investigate the interaction of measured with [ H]MK-801 autoradiography, was signifi- gonadal hormones with NMDA receptor-mediated locomotor cantly higher in male than in female mice but was not signif- hyperactivity and PPI disruption in mice. icantly altered by either castration or OVX. Results The effect of 0.25 mg/kg of MK-801 on locomotor Conclusions These results suggest that male sex hormones activity was greater in male mice than in female mice. enhance the effect of NMDA receptor

Journal

PsychopharmacologySpringer Journals

Published: Jul 3, 2017

References

You’re reading a free preview. Subscribe to read the entire article.


DeepDyve is your
personal research library

It’s your single place to instantly
discover and read the research
that matters to you.

Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.

All for just $49/month

Explore the DeepDyve Library

Search

Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly

Organize

Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.

Access

Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.

Your journals are on DeepDyve

Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.

All the latest content is available, no embargo periods.

See the journals in your area

DeepDyve

Freelancer

DeepDyve

Pro

Price

FREE

$49/month
$360/year

Save searches from
Google Scholar,
PubMed

Create lists to
organize your research

Export lists, citations

Read DeepDyve articles

Abstract access only

Unlimited access to over
18 million full-text articles

Print

20 pages / month

PDF Discount

20% off