Am J Cardiovasc Drugs (2018) 18:109–115 https://doi.org/10.1007/s40256-017-0250-3 ORIGINAL RESEARCH ARTICLE Selective BET Protein Inhibition with Apabetalone and Cardiovascular Events: A Pooled Analysis of Trials in Patients with Coronary Artery Disease 1 2 3 3 • • • • Stephen J. Nicholls Kausik K. Ray Jan O. Johansson Alan Gordon 3 3 3 3 • • • • Michael Sweeney Chris Halliday Ewelina Kulikowski Norman Wong 1 4 Susan W. Kim Gregory G. Schwartz Published online: 12 October 2017 Springer International Publishing AG 2017 Abstract dyslipidemia, and be undertreated with ß-blocker and anti- Background Inhibition of bromodomain and extra-terminal platelet agents. Treatment with apabetalone produced the (BET) proteins can modulate lipoprotein and inﬂammatory following dose-dependent changes compared with placebo: factors that mediate atherosclerosis. The impact of the BET increases in apolipoprotein A-I (apoA-I) of up to 6.7% inhibitor, apabetalone, on cardiovascular events is unknown. (P \ 0.001), increases in high-density lipoprotein choles- Objective Our objective was to investigate the impact of terol (HDL-C) of up to 6.5% (P \ 0.001), increases in apabetalone on cardiovascular event rates in a pooled large HDL particles of up to 23.3% (P\ 0.001), and analysis of clinical studies in patients with established decreases in
American Journal of Cardiovascular Drugs – Springer Journals
Published: Oct 12, 2017
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