Secukinumab/ustekinumab Reactions 1680, p304 - 2 Dec 2017 Paradoxical psoriasis: 2 case reports In a monocentric retrospective observational study of five patients, a 37-year-old woman and a 46-year-old woman developed paradoxical psoriasis during treatment with ustekinumab (1 patient) or secukinumab (1 patient) [routes and outcomes not stated]. Patient 1: A 37-year-old woman, who was diagnosed with SAPHO syndrome characterised by palmoplantar pustulosis since three years, received treatment with ustekinumab 90mg. Subsequently, she developed paradoxical psoriasis. After six months of the treatment, ustekinumab was discontinued. Patient 2: A 46-year-old woman, who was diagnosed with SAPHO syndrome characterised by palmoplantar pustulosis since five years, received treatment with secukinumab 150mg. Subsequently, she developed paradoxical psoriasis. After three months of the treatment, secukinumab was discontinued. Author comment: "No particular safety concerns were reported, except cases of paradoxical psoriasis flare(contributing to discontinuation of treatment) in one under ustekinumab, and the other case under secukinumab." Wendling D, et al. IL-23/Th17 targeted therapies in SAPHO syndrome. A case series. Joint Bone Spine 84: 733-735, No. 6, Dec 2017. Available from: URL: - France 803284087 0114-9954/17/1680-0001/$14.95 Adis © 2017 Springer International Publishing AG. All rights reserved Reactions 2 Dec 2017 No. 1680 Reactions Weekly Springer Journals


Reactions Weekly , Volume 1680 (1) – Dec 2, 2017
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Springer International Publishing
Copyright © 2017 by Springer International Publishing AG, part of Springer Nature
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
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