PharmacoEconomics & Outcomes News 804, p31 - 2 Jun 2018 uncertainty in results in the biologic-naıve population. Secukinumab cost effective for "Even at list price, secukinumab appears to represent a active disease in UK cost-effective use of NHS resources for biologic-naıve and biologic-experienced patients with active AS," the Secukinumab appears to be cost effective in adults in authors concluded. "This research highlights a continued the UK with active psoriatic arthritis (PsA) and active need for longer-term data on all biologic treatments in ankylosing spondylitis (AS) with inadequate response to this indication to help inform future cost-effectiveness previous treatment, according to findings of two analyses," they said. Novartis-funded cost-utility studies published in 1,2 PharmacoEconomics. * 2017 British pounds ** nonsteroidal anti-inflammatory drugs and non-pharmacological Psoriatic arthritis interventions such as physiotherapy A 3-month decision tree leading into a Markov model 1. Buchanan V, et al. Cost Effectiveness of Secukinumab for the Treatment of populated with data from the FUTURE 2 trial and a Active Psoriatic Arthritis in the UK. PharmacoEconomics : 25 May 2018. network meta-analysis was used to evaluate the Available from: URL: https://doi.org/10.1007/s40273-018-0674-x. 2. Emery P, et al. Cost Effectiveness of Secukinumab for the Treatment of Active cost effectiveness of secukinumab compared with Ankylosing Spondylitis in the UK. PharmacoEconomics : 25 May 2018. tumour necrosis factor inhibitors (TNFis) or standard of Available from: URL: https://doi.org/10.1007/s40273-018-0675-9. care in adults with active PsA who were TNFi-naıve, had 803324247 no concomitant moderate-to-severe psoriasis, and had inadequate response to conventional systemic disease- modifying anti-rheumatic drugs (csDMARDs). Cost effectiveness was assessed from the UK National Health Service (NHS) perspective over a 40-year time horizon. The estimated incremental cost-effectiveness ratio (ICER) for secukinumab compared with standard of care was £28 748 per QALY gained in patients who had received one prior csDMARD. In patients who had received two or more prior csDMARDs, secukinumab dominated (more effective and less costly) certolizumab pegol, etanercept and golimumab, had an ICER of £5680 per QALY gained versus adalimumab and saved over £1 million per QALY foregone versus infliximab. At a willingness-to-pay threshold between £20 000 and £30 000 per QALY gained, secukinumab had 48.9% probability of having the highest net monetary benefit in patients who had received one prior csDMARD, and 88.9% probability in patients who had received two or more prior csDMARDs. "Secukinumab 150 mg at list price appears to represent a cost-effective use of NHS resources for adults with PsA who have responded inadequately to one or two or more prior csDMARDs," concluded the authors. Ankylosing spondylitis A 3-month decision tree leading into a Markov model populated with data from the MEASURE 1 and 2 trials was used to evaluate the cost effectiveness of secukinumab, compared with licensed TNFis including biosimilars, in adults with active AS who had not responded adequately to previous treatment with ** conventional care (biologic-naıve) or previous biologic therapy (biologic-experienced), from the perspective of the UK NHS over a 40-year (lifetime) time horizon. In the biologic-naıve population, secukinumab dominated adalimumab and certolizumab pegol. ICERs versus other comparators were either below £10 000 per QALY gained or south-west ICERs that implied that secukinumab was cost effectiveness. All interventions other than secukinumab, etanercept biosimilar and infliximab biosimilar were dominated or extendedly dominated. The ICER for secukinumab versus etanercept biosimilar was £7524 per QALY gained, and the ICER for infliximab biosimilar versus secukinumab was £657 820 per QALY gained. In biologic-experienced patients, the ICER for secukinumab versus conventional care was £4927 per QALY gained. Probabilistic sensitivity analysis identified 1173-5503/18/0804-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved PharmacoEconomics & Outcomes News 2 Jun 2018 No. 804
PharmacoEconomics & Outcomes News – Springer Journals
Published: Jun 2, 2018
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