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Secukinumab

Secukinumab Reactions 1704, p339 - 2 Jun 2018 First report of cutaneous lichen planus: case report A 56-year-old man developed cutaneous lichen planus during treatment with secukinumab [dosage and route not stated] for chronic plaque psoriasis. The man had chronic plaque psoriasis. He presented with a 2 month history of violaceous and pruritic, thickened plaques on his bilateral lower limbs and buttocks during treatment with secukinumab for psoriasis. Initially, the plaques developed at his ankles and progressed gradually to proximally to his thighs and buttocks. The plaques demonstrated Wickham striae. Histology test revealed a band-like lymphocyte inflammatory infiltrate just beneath the epithelium with basal epithelial apoptoses. The man was started treated with betamethasone dipropionate which had moderate effect [time to reaction onset not stated]. Author comment: "We report the first case of drug- induced cutaneous [lichen planus] in the setting of secukinumab for treatment of chronic plaque psoriasis. " Doolan B, et al. Cutaneous lichen planus induced by secukinumab. Australasian Journal of Dermatology 59 (Suppl. 1): 60-61, May 2018. Available from: URL: http://doi.org/10.1111/ajd.17_12815 [abstract] - Australia 803323605 » Editorial comment: A search of AdisBase, Medline and Embase did not reveal any previous case reports of cutaneous lichen planus associated with http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Reactions Weekly Springer Journals

Secukinumab

Reactions Weekly , Volume 1704 (1) – Jun 2, 2018
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Secukinumab

Abstract

Reactions 1704, p339 - 2 Jun 2018 First report of cutaneous lichen planus: case report A 56-year-old man developed cutaneous lichen planus during treatment with secukinumab [dosage and route not stated] for chronic plaque psoriasis. The man had chronic plaque psoriasis. He presented with a 2 month history of violaceous and pruritic, thickened plaques on his bilateral lower limbs and buttocks during treatment with secukinumab for psoriasis. Initially, the plaques developed at his ankles and...
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References (1)

  • A. Adams, C. Rowe, D. Burdon‐Jones, D. Whiteman, B. Panizza, B. De, Ambrosis, C. McLean, R. Wolfe, G. Mcarthur, A. Haydon, T. Tra, N. Cummings, V. Mar (2018)

    Poster Presentations

    Australasian Journal of Dermatology, 59

Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer International Publishing AG, part of Springer Nature
Subject
Medicine & Public Health; Drug Safety and Pharmacovigilance; Pharmacology/Toxicology
ISSN
0114-9954
eISSN
1179-2051
DOI
10.1007/s40278-018-46982-y
Publisher site
See Article on Publisher Site

Abstract

Reactions 1704, p339 - 2 Jun 2018 First report of cutaneous lichen planus: case report A 56-year-old man developed cutaneous lichen planus during treatment with secukinumab [dosage and route not stated] for chronic plaque psoriasis. The man had chronic plaque psoriasis. He presented with a 2 month history of violaceous and pruritic, thickened plaques on his bilateral lower limbs and buttocks during treatment with secukinumab for psoriasis. Initially, the plaques developed at his ankles and progressed gradually to proximally to his thighs and buttocks. The plaques demonstrated Wickham striae. Histology test revealed a band-like lymphocyte inflammatory infiltrate just beneath the epithelium with basal epithelial apoptoses. The man was started treated with betamethasone dipropionate which had moderate effect [time to reaction onset not stated]. Author comment: "We report the first case of drug- induced cutaneous [lichen planus] in the setting of secukinumab for treatment of chronic plaque psoriasis. " Doolan B, et al. Cutaneous lichen planus induced by secukinumab. Australasian Journal of Dermatology 59 (Suppl. 1): 60-61, May 2018. Available from: URL: http://doi.org/10.1111/ajd.17_12815 [abstract] - Australia 803323605 » Editorial comment: A search of AdisBase, Medline and Embase did not reveal any previous case reports of cutaneous lichen planus associated with

Journal

Reactions Weekly – Springer Journals

Published: Jun 2, 2018

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