Reactions 1704, p339 - 2 Jun 2018 First report of cutaneous lichen planus: case report A 56-year-old man developed cutaneous lichen planus during treatment with secukinumab [dosage and route not stated] for chronic plaque psoriasis. The man had chronic plaque psoriasis. He presented with a 2 month history of violaceous and pruritic, thickened plaques on his bilateral lower limbs and buttocks during treatment with secukinumab for psoriasis. Initially, the plaques developed at his ankles and progressed gradually to proximally to his thighs and buttocks. The plaques demonstrated Wickham striae. Histology test revealed a band-like lymphocyte inflammatory infiltrate just beneath the epithelium with basal epithelial apoptoses. The man was started treated with betamethasone dipropionate which had moderate effect [time to reaction onset not stated]. Author comment: "We report the first case of drug- induced cutaneous [lichen planus] in the setting of secukinumab for treatment of chronic plaque psoriasis. " Doolan B, et al. Cutaneous lichen planus induced by secukinumab. Australasian Journal of Dermatology 59 (Suppl. 1): 60-61, May 2018. Available from: URL: http://doi.org/10.1111/ajd.17_12815 [abstract] - Australia 803323605 » Editorial comment: A search of AdisBase, Medline and Embase did not reveal any previous case reports of cutaneous lichen planus associated with secukinumab. The results from the WHO ADR database are pending. 0114-9954/18/1704-0001/$14.95 Adis © 2018 Springer International Publishing AG. All rights reserved Reactions 2 Jun 2018 No. 1704
Reactions Weekly – Springer Journals
Published: Jun 2, 2018
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