Secondary structure analysis of swine pasivirus (family Picornaviridae ) RNA reveals a type-IV IRES and a parechovirus-like 3’ UTR organization

Secondary structure analysis of swine pasivirus (family Picornaviridae ) RNA reveals a type-IV... The potential RNA structures of the 5’ and 3’ untranslated regions (UTRs) and cis -acting replication elements (CREs) of a novel pasivirus (PaV) genotype (family Picornaviridae ) were analysed. PaV-A3 (KM259923) was identified in a faecal sample from a domestic pig in Hungary with posterior paraplegia of unknown etiology. Based on likely structural features of the 5’ UTR, the pasiviruses were inferred to possess Hepacivirus / Pestivirus -like type-IV IRES. The pasivirus CRE was mapped to the 2B genome region, similar to Ljungan virus. The secondary RNA structure of the pasivirus 3’ UTR was structurally similar to that of human parechoviruses. The genome, CRE, and 3’ UTR of pasiviruses provide further evidence of the common origin of the members of the genera Parechovirus and Pasivirus, although their different 5’ UTR IRES types suggest that a recombination event occurred during the divergence these viruses. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Virology Springer Journals

Secondary structure analysis of swine pasivirus (family Picornaviridae ) RNA reveals a type-IV IRES and a parechovirus-like 3’ UTR organization

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Publisher
Springer Vienna
Copyright
Copyright © 2015 by Springer-Verlag Wien
Subject
Biomedicine; Virology; Medical Microbiology; Infectious Diseases
ISSN
0304-8608
eISSN
1432-8798
D.O.I.
10.1007/s00705-015-2371-9
Publisher site
See Article on Publisher Site

References

  • Cis-active RNA elements (CREs) and picornavirus RNA replication
    Steil, BP; Barton, DJ

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