DOI 10.1007/s10600-018-2406-z Chemistry of Natural Compounds, Vol. 54, No. 3, May, 2018 SECONDARY METABOLITES ISOLATED FROM THE GORGONIAN-DERIVED FUNGUS Aspergillus ruber AND THEIR ANTIVIRAL ACTIVITY 1,2 1 Ting-Mei Liang, Yao-Wei Fang, 2 1,2* Ji-Yong Zheng, and Chang-Lun Shao Herpes simplex virus type-1 (HSV-1) is a widespread ancient human pathogen which is most commonly associated with subclinical and mild infections . HSV-1 infects the majority of the population resulting in transient cold sores or asymptomatic infection that persists lifelong in the sensory ganglia of the infected individuals . It is imperative to develop new and effective anti-HSV drugs. During the last two decades, marine microorganisms have received growing attention as one of the most prolific sources for bioactive metabolites and have great potential to increase the number of marine natural products in clinical trials . Six compounds (1–6) were isolated from the fungus Aspergillus ruber collected from the Xisha Islands. Two benzaldehyde derivatives (1 and 2) showed significant antiviral activity against HSV-1 virus, and compound 1 showed weak antibacterial activity. Herein we report the isolation, structure elucidation, and biological activity of these compounds (1–6). Fungal Materials. The fungal strain A. ruber (H-1) was isolated from gorgonians (XS-2009-13) collected from the
Chemistry of Natural Compounds – Springer Journals
Published: Jun 7, 2018
It’s your single place to instantly
discover and read the research
that matters to you.
Enjoy affordable access to
over 18 million articles from more than
15,000 peer-reviewed journals.
All for just $49/month
Query the DeepDyve database, plus search all of PubMed and Google Scholar seamlessly
Save any article or search result from DeepDyve, PubMed, and Google Scholar... all in one place.
Get unlimited, online access to over 18 million full-text articles from more than 15,000 scientific journals.
Read from thousands of the leading scholarly journals from SpringerNature, Elsevier, Wiley-Blackwell, Oxford University Press and more.
All the latest content is available, no embargo periods.
“Hi guys, I cannot tell you how much I love this resource. Incredible. I really believe you've hit the nail on the head with this site in regards to solving the research-purchase issue.”Daniel C.
“Whoa! It’s like Spotify but for academic articles.”@Phil_Robichaud
“I must say, @deepdyve is a fabulous solution to the independent researcher's problem of #access to #information.”@deepthiw
“My last article couldn't be possible without the platform @deepdyve that makes journal papers cheaper.”@JoseServera