Drug Saf (2017) 40:771–781 DOI 10.1007/s40264-017-0543-0 SYSTEMATIC REVIEW Second-Generation Antipsychotics and Metabolic Side Effects: A Systematic Review of Population-Based Studies 1,2,4 3 1,4,5 1,2,3,4 • • • • Lauren Hirsch Jaeun Yang Lauren Bresee Nathalie Jette 1,2,3,4 6 Scott Patten Tamara Pringsheim Published online: 5 June 2017 Springer International Publishing Switzerland 2017 Abstract metabolic outcome such as type 2 diabetes mellitus, dys- Introduction There is strong evidence from randomized lipidemia, obesity, hypertension, or metabolic syndrome. controlled trials (RCTs) that second-generation antipsy- Methods A systematic search process was used to identify chotic (SGA) medications are associated with metabolic studies for inclusion in this review. Included studies had to adverse events. However, with the recent increases in the be population-based studies of users of any SGA medica- use of SGAs worldwide and frequent off-label use, it is tion with at least one reported metabolic outcome. Study unclear whether these associations are generalizable to quality was also assessed using the AMSTAR tool, and populations beyond those included in RCTs. evidence was synthesized by both metabolic outcome and Objectives This review aims to characterize the impact of speciﬁc SGA medication. SGAs on the population through a systematic review of Results In total, 15
Drug Safety – Springer Journals
Published: Jun 5, 2017
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