Curr Stem Cell Rep (2017) 3:181–191 DOI 10.1007/s40778-017-0088-2 IN VITRO AND IN VIVO MODELS IN STEM CELL BIOLOGY (E SCOTT, SECTION EDITOR) BSea^-ing Is Believing: In Vivo Imaging of Hematopoietic Stem Cells and Cancer Using Zebrafish 1,2 1,2 1,2,3 Samima Habbsa & Mia McKinstry & Teresa V. Bowman Published online: 10 July 2017 Springer International Publishing AG 2017 . . . Abstract Keywords Zebrafish Hematopoietic stem cells Cancer . . Purpose of Review Communication between cells and their Imaging Transplantation Development environment regulates their behaviors. Like a naturalist who watches animals to understand them, visualizing cells within their native ecosystems provides clues into how they work. In Introduction this review, we discuss recent findings using in vivo imaging in zebrafish to understand the behaviors of hematopoietic stem Hematopoietic stem and progenitor cells (HSPCs) possess the and progenitor cells (HSPCs) and cancer. ability to self-renew and differentiate, properties also Recent Findings Recent studies visualizing the birth and mi- employed by cancer cells. Additionally, both HSPCs and can- gration of HSPCs throughout development and adulthood cer cells have the ability to leave their primary location and have revealed the contributions of signals from somites, im- make a new home at a
Current Stem Cell Reports – Springer Journals
Published: Jul 10, 2017
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