Mammalian Genome 11, 528–530 (2000). DOI: 10.1007/s003350010101 Incorporating Mouse Genome © Springer-Verlag New York Inc. 2000 Screening for dysmorphological abnormalities—a powerful tool to isolate new mouse mutants 1 2 3 4 1 Helmut Fuchs, Klaus Schughart, Eckhard Wolf, Rudi Balling, Martin Hrabe ´ de Angelis GSF Research Center, Institute for Experimental Genetics, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany Transgene S.A., 11 Rue de Molsheim, 67082 Strasbourg, France Institute of Molecular Animal Breeding, Gene Center, Ludwig-Maximilian University, Feodor-Lynen-Strasse 25, D-81377 Munich, Germany GSF Research Center, Institute for Mammalian Genetics, Ingolstaedter Landstrasse 1, 85764 Neuherberg, Germany Received 16 December 1999 / Accepted: 16 December 1999 Introduction In the dysmorphology screen, we look for both dominant and recessive mutations. Many dominant phenotypic alterations are relatively easy to detect and, in many cases, dominant phenotypes Phenotypic and genotypic analysis of mouse mutants has proven to are associated with abnormal development in homozygous em- be an extremely successful approach towards the understanding of morphological abnormalities and their genetic basis. Over the last bryos. For example, the Small eye mutant exhibits small eyes in few decades, many mouse mutant lines have been collected that the heterozygous state, but lacks eyes in the homozygous state (see
Mammalian Genome – Springer Journals
Published: Feb 25, 2014
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