Scorpion Venom–Toxins that Aid in Drug Development: A Review

Scorpion Venom–Toxins that Aid in Drug Development: A Review Scorpion venom components have multifaceted orientation against bacterial, viral, fungal infections and other neuronal + + − 2+ disorders. They can modulate the ion channels (K, Na, Cl, Ca ) of our body and this concept has been hypothesized in formulating pharmaceuticals. The triumphant achievement of these venom components as formulated anticancer agent in Phase I and Phase II clinical trials allure researchers to excavate beneficial venom components prohibiting DNA replication in malignant tumor cells. This review brings forth the achievements of Science and Technology in classifying the venom components as therapeutics and further application in drug product development. Keywords Venom toxins · Ion channels · Arthropods · Peptides · Pharmaceuticals Introduction plasma with snake venom (obtained from Bothrops jara- raca). Arthropod envenomation is usually common during Science has always seized attention towards unusual things the summer months of the year due to increased agricul- and if harvested, acts as a potent cure for human disorders. tural activities (Bawaskar and Bawaskar 2012). They secrete Poisonous, venom producing organisms, being a cause of venom in response to external stimuli to capture prey, sur- mortality, have been a source of medicine to human syn- vive from predators and hence build a dynasty on this planet. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png International Journal of Peptide Research and Therapeutics Springer Journals

Scorpion Venom–Toxins that Aid in Drug Development: A Review

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Publisher
Springer Journals
Copyright
Copyright © 2018 by Springer Science+Business Media, LLC, part of Springer Nature
Subject
Life Sciences; Biochemistry, general; Animal Anatomy / Morphology / Histology; Polymer Sciences; Pharmaceutical Sciences/Technology; Pharmacology/Toxicology; Molecular Medicine
ISSN
1573-3149
eISSN
1573-3904
D.O.I.
10.1007/s10989-018-9721-x
Publisher site
See Article on Publisher Site

Abstract

Scorpion venom components have multifaceted orientation against bacterial, viral, fungal infections and other neuronal + + − 2+ disorders. They can modulate the ion channels (K, Na, Cl, Ca ) of our body and this concept has been hypothesized in formulating pharmaceuticals. The triumphant achievement of these venom components as formulated anticancer agent in Phase I and Phase II clinical trials allure researchers to excavate beneficial venom components prohibiting DNA replication in malignant tumor cells. This review brings forth the achievements of Science and Technology in classifying the venom components as therapeutics and further application in drug product development. Keywords Venom toxins · Ion channels · Arthropods · Peptides · Pharmaceuticals Introduction plasma with snake venom (obtained from Bothrops jara- raca). Arthropod envenomation is usually common during Science has always seized attention towards unusual things the summer months of the year due to increased agricul- and if harvested, acts as a potent cure for human disorders. tural activities (Bawaskar and Bawaskar 2012). They secrete Poisonous, venom producing organisms, being a cause of venom in response to external stimuli to capture prey, sur- mortality, have been a source of medicine to human syn- vive from predators and hence build a dynasty on this planet.

Journal

International Journal of Peptide Research and TherapeuticsSpringer Journals

Published: Jun 5, 2018

References

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