ISSN 1062-3604, Russian Journal of Developmental Biology, 2009, Vol. 40, No. 6, p. 395. © Pleiades Publishing, Inc., 2009. Original Russian Text © V.Yu. Polyakov, 2009, published in Ontogenez, 2009, Vol. 40, No. 6, p. 480. CHRONICLE Scientific and Practical Conference “Modern Biological Methods for Reproductive Medicine” (February 25, 2009, Moscow, Russia) DOI: 10.1134/S1062360409060101 The scientiﬁc and practical conference on the modern (SSC) and Sertoli cells (SSC niche) and illustrated suc- biological methods for reproductive medicine was held in cessful development of the methods for SSC isolation, cul- the Kol’tsov Institute of Developmental Biology, Russian tivation, and transplantation, offering great opportunities Academy of Sciences, on February 25th, 2009. for practical medicine, construction of transgenic animals, preservation of rare and endangered species, and in vitro The goals of this conference were to expand the modern modeling of spermatogenesis. concepts of the pathogenesis of some diseases affecting the S.A. Yakovenko (Physical Faculty, Moscow State Uni- reproductive system, assist in introduction of the state-of- versity) presented a developed original microscopic device the-art results of molecular biological and cellular studies providing for resolving low-contrast vacuoles with a size of to the diagnostics of fertility abnormalities, and increase about 0.1 μm in the spermatozoid head. Use of spermato- the efﬁciency of infertility therapy and reproductive tech- zoids without vacuoles considerably increases the rate of nologies. successful pregnancies when using one of the reproductive The presentation by L.F. Kurilo (Medical Genetic technologies---intracytoplasmic injection of spermatozo- Research Center of the Russian Academy of Medical Sci- ids into the ovum. ences) considered the genetic mechanisms underlying After hearing and discussing the presentations, the con- morphogenetic and functional pathologies of the reproduc- ference participants developed recommendations underlin- tive system and the opportunities offered for diagnostics ing that and prevention of various pathologies. (1) It is necessary to develop the standards (protocols) E.E. Bragina (Belozersky Institute of Physicochemical for combined examination of the patients with reproductive Biology, Moscow State University) presented the results of pathologies using state-of-the-art genetic, cytological, ultrastructural studies of human spermatozoids. Quantita- ultrastructural, and molecular biological techniques; tive ultrastructural analysis of the chromatin in spermato- zoids demonstrates that a 28% rate of spermatozoids with (2) It is purposeful to use ultrastructural, virological, abnormal chromatin condensation is critical for the devel- and cytogenetic analyses of male gametes in the case of opment of an embryo. Bragina also showed the data on the miscarriages and unsuccessful application of reproductive intragametic herpes infection of human spermatozoids and technologies; that an abnormality in the centriole structure could cause (3) It is purposeful to discuss the topical problems con- idiopathic impairment of embryo development. nected with the deﬁciency in medical geneticists and the The topic of presentation by A.A. Kushch (Ivanovsky staff of some other specialties required for complex diag- Institute of Virology, Russian Academy of Medical Sci- nostic and research procedures (cytogenetics), because ences) was the study of the rate of detection of the herpes biologists cannot attend certiﬁcation courses on a regular simplex virus (HSV) in the sperm ejaculate of men with basis; and impaired fertility and the evidence for a negative HSV (4) The scientiﬁc developments in the ﬁeld of diagnos- effect on sperm quality. HSV is signiﬁcantly more fre- tics, therapy, and prevention of abnormalities in the repro- quently detected in both the whole ejaculate and the frac- ductive health under the national project of demographic tion of actively moving spermatozoids of the man cohort development in Russia are a priority direction. with primary infertility as compared with practically healthy individuals. Infective HSV can be released in the It was proposed to organize on a regular basis the con- case of an asymptomatic herpes virus infection. ferences that would inform reproductologists, gynecolo- gists, andrologists, and laboratory staff working in practical The lecture of a group of authors (A.Yu. Kulibin, medicine about the relevant modern biological methods. T.L. Marshak, and S.T. Zakhidov; Kol’tsov Institute of Developmental Biology, Russian Academy of Sciences, V.Yu. Polyakov and Moscow State University) dwelled on the modern concepts in the biology of spermatogonial stem cells E-mail: email@example.com
Russian Journal of Developmental Biology – Springer Journals
Published: Dec 3, 2009
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